Analysis of the 5-HT2 receptor ligands dimethoxy-4-indophenyl-2- aminopropane and ketanserin in ethanol discriminations

Kendall T. Szeliga, Kathleen A. Grant

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Previous studies have suggested a modulatory role of the 5-HT2 receptor system in the behavioral effects of ethanol. The present study examined the discriminative stimulus effects of the 5-HT(2A/2C) agonist (-)-dimethoxy-4- indophenly-2-aminopropane (DOI) and the 5-HT(2A) antagonist ketanserin in rats trained to discriminate either 1.5 g/kg of ethanol from water (intragastrically, n = 7) or 2.0 g/kg of ethanol from water (intragastrically, n = 8). In substitution tests, neither DOI (0.3 to 1.0 mg/kg, ip) nor ketanserin (3.0 to 17.0 mg/kg, ip) produced discriminative stimulus effects similar to either training dose of ethanol, although decreases in rates of responding were significant at the highest doses tested. Likewise, when given in combination with ethanol, neither 5-HT2 ligand shifted the ethanol-dose response determination in either the 1.5 or 2.0 g/kg ethanol training groups. DOI in combination with ethanol did not alter rates of responding, whereas ketanserin in combination with ethanol significantly decreased response rates. Thus, the 5-HT(2A) receptor ligands do not appreciably affect the discriminative stimulus effects of ethanol, in contrast to previous results with 5-HT(1B) ligands.

Original languageEnglish (US)
Pages (from-to)646-651
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume22
Issue number3
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • 5-HT Receptors
  • Drug Discrimination
  • Ethanol
  • Rats
  • Serotonin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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