Analysis of speed, curvature, planarity and frequency characteristics of heart vector movement to evaluate the electrophysiological substrate associated with ventricular tachycardia

Larisa Tereshchenko, Jonathan W. Waks, Muammar Kabir, Elyar Ghafoori, Alexei Shvilkin, Mark E. Josephson

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Background: We developed a novel method of assessing ventricular conduction using the surface ECG. Methods: Orthogonal ECGs of 81 healthy controls (age 39.0±14.2 y; 51.8% males; 94% white), were compared with iDower-transformed 12-lead ECGs (both 1000. Hz), recorded in 8 patients with infarct-cardiomyopathy and sustained monomorphic ventricular tachycardia (VT) (age 68.0±7.8. y, 37.5% male, mean LVEF 29±12%). Normalized speed at 10 QRS segments was calculated as the distance traveled by the heart vector along the QRS loop in three-dimensional space, divided by 1/10th of the QRS duration. Curvature was calculated as the magnitude of the derivative of the QRS loop tangent vector divided by speed. Planarity was calculated as the mean of the dihedral angles between 2 consecutive planes for all planes generated for the median beat. Orbital frequency (a scalar measure of rotation rate of the QRS vector) was calculated as a product of speed and curvature. Results: Mixed regression analysis showed that speed was slower [6.6 (95%CI 4.4-8.9) vs. 24.6 (95%CI 11.5-37.7)V/ms; P-1; P

    Original languageEnglish (US)
    Pages (from-to)150-160
    Number of pages11
    JournalComputers in Biology and Medicine
    Volume65
    DOIs
    StatePublished - Oct 1 2015

    Fingerprint

    Ventricular Tachycardia
    Electrocardiography
    Substrates
    Cardiomyopathies
    Dihedral angle
    Regression Analysis
    Regression analysis
    Lead
    Derivatives

    Keywords

    • Conduction velocity
    • Curvature
    • Frequency characteristics
    • Heart vector
    • Planarity
    • Speed
    • Vectorcardiography
    • Ventricular tachycardia

    ASJC Scopus subject areas

    • Computer Science Applications
    • Health Informatics

    Cite this

    Analysis of speed, curvature, planarity and frequency characteristics of heart vector movement to evaluate the electrophysiological substrate associated with ventricular tachycardia. / Tereshchenko, Larisa; Waks, Jonathan W.; Kabir, Muammar; Ghafoori, Elyar; Shvilkin, Alexei; Josephson, Mark E.

    In: Computers in Biology and Medicine, Vol. 65, 01.10.2015, p. 150-160.

    Research output: Contribution to journalArticle

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    AU - Ghafoori, Elyar

    AU - Shvilkin, Alexei

    AU - Josephson, Mark E.

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