Analysis of small vessel cochlear blood flow regulation during loud sound exposure in the mouse

George W.S. Burwood; Suzan Dziennis; Teresa Wilson; Jianlong Yang; Gangjun Liu; Sarah Foster; Ruikang Wang; Alfred Nuttall

doi:10.1117/12.2505434

Analysis of small vessel cochlear blood flow regulation during loud sound exposure in the mouse

George W.S. Burwood, Suzan Dziennis, Teresa Wilson, Jianlong Yang, Gangjun Liu, Sarah Foster, Ruikang Wang, Alfred Nuttall

Ophthalmology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Using optical coherence tomography angiography, we measured blood flow from the vessels in the lateral wall in the mouse cochlea directly through bone in mice with and without sympathetic neuronal function. We present in vivo imaging of blood flow and mechanical vibration in mice subjected to 30 min of loud sound. Loud sound caused blood flow reduction. In mice with superior cervical ganglion ablation, the loud sound-induced reduction in blood flow was partially ameliorated. These results demonstrate that sympathetic innervation likely plays a role in the pathological decrease in blood flow observed in the lateral wall vessels in response to loud sound.

Original language	English (US)
Title of host publication	Tenth International Conference on Information Optics and Photonics
Editors	Yidong Huang
Publisher	SPIE
Volume	10964
ISBN (Electronic)	9781510625792
DOIs	https://doi.org/10.1117/12.2505434
State	Published - Jan 1 2018
Event	10th International Conference on Information Optics and Photonics - Beijing, China Duration: Jul 8 2018 → Jul 11 2018

Other

Other	10th International Conference on Information Optics and Photonics
Country	China
City	Beijing
Period	7/8/18 → 7/11/18

Fingerprint

Keywords

Blood flow
Cochlea
Imaging systems
Medical optics and biotechnology
Noiseinduced hearing loss
Optical coherence tomography

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Cite this

Burwood, G. W. S., Dziennis, S., Wilson, T., Yang, J., Liu, G., Foster, S., Wang, R., & Nuttall, A. (2018). Analysis of small vessel cochlear blood flow regulation during loud sound exposure in the mouse. In Y. Huang (Ed.), Tenth International Conference on Information Optics and Photonics (Vol. 10964). [109641R] SPIE. https://doi.org/10.1117/12.2505434

Analysis of small vessel cochlear blood flow regulation during loud sound exposure in the mouse. / Burwood, George W.S.; Dziennis, Suzan; Wilson, Teresa; Yang, Jianlong; Liu, Gangjun; Foster, Sarah; Wang, Ruikang; Nuttall, Alfred.

Tenth International Conference on Information Optics and Photonics. ed. / Yidong Huang. Vol. 10964 SPIE, 2018. 109641R.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Burwood, GWS, Dziennis, S, Wilson, T, Yang, J, Liu, G, Foster, S, Wang, R & Nuttall, A 2018, Analysis of small vessel cochlear blood flow regulation during loud sound exposure in the mouse. in Y Huang (ed.), Tenth International Conference on Information Optics and Photonics. vol. 10964, 109641R, SPIE, 10th International Conference on Information Optics and Photonics, Beijing, China, 7/8/18. https://doi.org/10.1117/12.2505434

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AB - Using optical coherence tomography angiography, we measured blood flow from the vessels in the lateral wall in the mouse cochlea directly through bone in mice with and without sympathetic neuronal function. We present in vivo imaging of blood flow and mechanical vibration in mice subjected to 30 min of loud sound. Loud sound caused blood flow reduction. In mice with superior cervical ganglion ablation, the loud sound-induced reduction in blood flow was partially ameliorated. These results demonstrate that sympathetic innervation likely plays a role in the pathological decrease in blood flow observed in the lateral wall vessels in response to loud sound.

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10.1117/12.2505434