Analysis of risk factors associated with prostate cancer extension to the surgical margin and pelvic node metastasis at radical prostatectomy

D. A. Ackerman, John Barry, R. A. Wicklund, N. Olson, B. A. Lowe

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

We analyzed data from 107 consecutive patients with clinical stage B prostate cancer in an attempt to identify those at high risk for having involved margins or nodal metastasis. Each patient underwent transrectal ultrasound-guided sextant biopsies of the prostate. Patient age, surgical approach to prostatectomy, pre-biopsy prostate specific antigen (PSA) level, and number, location and maximum Gleason score of positive biopsies were statistically evaluated for all patient groups. Prostate volume and PSA density (PSAD) were calculated for all patients undergoing prostatectomy. Of the 101 patients who underwent radical prostatectomy 64 had negative margins, 37 had at least 1 positive margin and 11 of the 37 had more than 1 positive margin. Involved margins were most common at the apex (62%) and mid portion (59%) of the gland. Prostatectomy was not performed on 6 patients with nodal metastases evident on frozen section examination. Therefore, 43 patients are considered to be at high risk for having residual disease after surgery. The mean PSAD, PSA level and number of positive biopsies were significant (p

Original languageEnglish (US)
Pages (from-to)1845-1850
Number of pages6
JournalJournal of Urology
Volume150
Issue number6
StatePublished - 1993

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Prostatectomy
Prostatic Neoplasms
Neoplasm Metastasis
Prostate-Specific Antigen
Biopsy
Prostate
Margins of Excision
Neoplasm Grading
Frozen Sections

Keywords

  • biopsy
  • prostatectomy
  • prostatic neoplasms
  • ultrasonography

ASJC Scopus subject areas

  • Urology

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Analysis of risk factors associated with prostate cancer extension to the surgical margin and pelvic node metastasis at radical prostatectomy. / Ackerman, D. A.; Barry, John; Wicklund, R. A.; Olson, N.; Lowe, B. A.

In: Journal of Urology, Vol. 150, No. 6, 1993, p. 1845-1850.

Research output: Contribution to journalArticle

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