Analysis of Renal Functional Outcomes after Radical or Partial Nephrectomy for Renal Masses ≥7 cm Using the RENAL Score

Ryan Kopp, Michael A. Liss, Reza Mehrazin, Song Wang, Hak J. Lee, Ramzi Jabaji, Hossein S. Mirheydar, Kyle Gillis, Nishant Patel, Kerrin L. Palazzi, Jim Y. Wan, Anthony L. Patterson, Ithaar H. Derweesh

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Abstract

Objective To determine if partial nephrectomy (PN) confers a renal functional benefit compared to radical nephrectomy (RN) for clinical T2 renal masses (T2RM) when adjusting for tumor complexity characterized by the RENAL nephrometry score. Methods A 2-center study of 202 patients with T2RM undergoing RN (122) or PN (80) (median follow-up, 41.5 months). RN and PN cohorts were subanalyzed according to RENAL sum as a categorical variable of 2). Results No significant differences existed between PN and RN for RENAL score. ΔeGFR was greater in RN (-19.7) vs PN (-11.9; P =.006). De novo CKD was 40.2% after RN vs 16.3% after PN (P 10, with larger relative decrease in eGFR for each decrease in RENAL sum. Further investigation is required to determine optimal candidates for PN in T2RM.

Original languageEnglish (US)
Pages (from-to)312-319
Number of pages8
JournalUrology
Volume86
Issue number2
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

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Nephrectomy
Kidney
varespladib methyl

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

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Analysis of Renal Functional Outcomes after Radical or Partial Nephrectomy for Renal Masses ≥7 cm Using the RENAL Score. / Kopp, Ryan; Liss, Michael A.; Mehrazin, Reza; Wang, Song; Lee, Hak J.; Jabaji, Ramzi; Mirheydar, Hossein S.; Gillis, Kyle; Patel, Nishant; Palazzi, Kerrin L.; Wan, Jim Y.; Patterson, Anthony L.; Derweesh, Ithaar H.

In: Urology, Vol. 86, No. 2, 01.08.2015, p. 312-319.

Research output: Contribution to journalArticle

Kopp, R, Liss, MA, Mehrazin, R, Wang, S, Lee, HJ, Jabaji, R, Mirheydar, HS, Gillis, K, Patel, N, Palazzi, KL, Wan, JY, Patterson, AL & Derweesh, IH 2015, 'Analysis of Renal Functional Outcomes after Radical or Partial Nephrectomy for Renal Masses ≥7 cm Using the RENAL Score', Urology, vol. 86, no. 2, pp. 312-319. https://doi.org/10.1016/j.urology.2015.02.067
Kopp, Ryan ; Liss, Michael A. ; Mehrazin, Reza ; Wang, Song ; Lee, Hak J. ; Jabaji, Ramzi ; Mirheydar, Hossein S. ; Gillis, Kyle ; Patel, Nishant ; Palazzi, Kerrin L. ; Wan, Jim Y. ; Patterson, Anthony L. ; Derweesh, Ithaar H. / Analysis of Renal Functional Outcomes after Radical or Partial Nephrectomy for Renal Masses ≥7 cm Using the RENAL Score. In: Urology. 2015 ; Vol. 86, No. 2. pp. 312-319.
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AU - Liss, Michael A.

AU - Mehrazin, Reza

AU - Wang, Song

AU - Lee, Hak J.

AU - Jabaji, Ramzi

AU - Mirheydar, Hossein S.

AU - Gillis, Kyle

AU - Patel, Nishant

AU - Palazzi, Kerrin L.

AU - Wan, Jim Y.

AU - Patterson, Anthony L.

AU - Derweesh, Ithaar H.

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N2 - Objective To determine if partial nephrectomy (PN) confers a renal functional benefit compared to radical nephrectomy (RN) for clinical T2 renal masses (T2RM) when adjusting for tumor complexity characterized by the RENAL nephrometry score. Methods A 2-center study of 202 patients with T2RM undergoing RN (122) or PN (80) (median follow-up, 41.5 months). RN and PN cohorts were subanalyzed according to RENAL sum as a categorical variable of 2). Results No significant differences existed between PN and RN for RENAL score. ΔeGFR was greater in RN (-19.7) vs PN (-11.9; P =.006). De novo CKD was 40.2% after RN vs 16.3% after PN (P 10, with larger relative decrease in eGFR for each decrease in RENAL sum. Further investigation is required to determine optimal candidates for PN in T2RM.

AB - Objective To determine if partial nephrectomy (PN) confers a renal functional benefit compared to radical nephrectomy (RN) for clinical T2 renal masses (T2RM) when adjusting for tumor complexity characterized by the RENAL nephrometry score. Methods A 2-center study of 202 patients with T2RM undergoing RN (122) or PN (80) (median follow-up, 41.5 months). RN and PN cohorts were subanalyzed according to RENAL sum as a categorical variable of 2). Results No significant differences existed between PN and RN for RENAL score. ΔeGFR was greater in RN (-19.7) vs PN (-11.9; P =.006). De novo CKD was 40.2% after RN vs 16.3% after PN (P 10, with larger relative decrease in eGFR for each decrease in RENAL sum. Further investigation is required to determine optimal candidates for PN in T2RM.

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