Analysis of myocardial and total body integral extraction ratios of rubidium-86.

P. F. McDonagh, A. F. Salel, Kenneth Krohn, E. A. Rhode, D. T. Mason

Research output: Contribution to journalArticle

Abstract

Coronary blood flow (QM) measurement with radiorubidium (Rb) assumes that Rb distributes to the myocardium in proportion to flow. This assumption is correct if the integral myocardial Rb extraction ratio (ERM) equals total body extraction (ERTB). A right-heart-bypass preparation was employed to test the hypothesis that ERM = ERTB and to examine the determinants of Rb extraction. Dogs were anesthetized with pentobarbital, and arterial, coronary venous, and total body venous Rb concentrations were continuously measured for 4 min after injection. We found that ERM (0.56 +/- 0.01) was significantly less than ERTB (0.70 +/- 0.01), P less than 0.01 (n = 29) and concluded that Rb did not distribute in proportion to flow. We do not recommend this method for clinical use. ERM is flow dependent and ERRB is a function of the total cardiac output and the distribution of cardiac output. Before employing Rb in animal experiments, it is recommended that a preliminary study be performed comparing flow measured with Rb to an independent measure of blood flow.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume235
Issue number6
StatePublished - Dec 1978
Externally publishedYes

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Rubidium
Cardiac Output
Right Heart Bypass
Pentobarbital
Myocardium
Dogs
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Analysis of myocardial and total body integral extraction ratios of rubidium-86. / McDonagh, P. F.; Salel, A. F.; Krohn, Kenneth; Rhode, E. A.; Mason, D. T.

In: The American journal of physiology, Vol. 235, No. 6, 12.1978.

Research output: Contribution to journalArticle

McDonagh, P. F. ; Salel, A. F. ; Krohn, Kenneth ; Rhode, E. A. ; Mason, D. T. / Analysis of myocardial and total body integral extraction ratios of rubidium-86. In: The American journal of physiology. 1978 ; Vol. 235, No. 6.
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