Analysis of molecular inversion probe performance for allele copy number determination

Yuker Wang, Martin Moorhead, George Karlin-Neumann, Nicholas J. Wang, James Ireland, Steven Lin, Chunnuan Chen, Laura M. Heiser, Koei Chin, Laura Esserman, Joe W. Gray, Paul T. Spellman, Malek Faham

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


We have developed a new protocol for using molecular inversion probes to accurately and specifically measure allele copy number. The new protocol provides for significant improvements, including the reduction of input DNA (from 2 μg) by more than 25-fold (to 75 ng total genomic DNA), higher overall precision resulting in one order of magnitude lower false positive rate, and greater dynamic range with accurate absolute copy number up to 60 copies.

Original languageEnglish (US)
Article numberR246
JournalGenome biology
Issue number11
StatePublished - Nov 20 2007
Externally publishedYes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology


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