Analysis of mixed leucocyte culture (MLC) reactive cells after in vitro priming. Changes in avidity of T cell receptors

Reginald M. Gorczynski, Marvin B. Rittenberg

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Abstract

Mixed leucocyte cultures were examined for populations of T cells responding to secondary stimulation with the priming antigen. Two such populations are described, one of which is stimulated optimally by low, the other by high doses of antigen. Both cell populations are sensitive to anti brain θ serum and complement, but are physically separable by size and by adherence on macrophage monolayers. The anti-brain θ-sensitive population stimulated by low antigen doses consists of larger cells with immunoglobulin-moieties on their surfaces.

Original languageEnglish (US)
Pages (from-to)171-181
Number of pages11
JournalCellular Immunology
Volume16
Issue number1
DOIs
StatePublished - Mar 1975

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ASJC Scopus subject areas

  • Immunology

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