Analysis of mixed leucocyte culture (MLC) reactive cells after in vitro priming. Changes in avidity of T cell receptors

Reginald M. Gorczynski, Marvin Rittenberg

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mixed leucocyte cultures were examined for populations of T cells responding to secondary stimulation with the priming antigen. Two such populations are described, one of which is stimulated optimally by low, the other by high doses of antigen. Both cell populations are sensitive to anti brain θ serum and complement, but are physically separable by size and by adherence on macrophage monolayers. The anti-brain θ-sensitive population stimulated by low antigen doses consists of larger cells with immunoglobulin-moieties on their surfaces.

Original languageEnglish (US)
Pages (from-to)171-181
Number of pages11
JournalCellular Immunology
Volume16
Issue number1
DOIs
StatePublished - 1975
Externally publishedYes

Fingerprint

T-Cell Antigen Receptor
Leukocytes
Cell Culture Techniques
Vulnerable Populations
Antigens
Brain
Population
Immunoglobulins
Macrophages
T-Lymphocytes
Serum
In Vitro Techniques

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Analysis of mixed leucocyte culture (MLC) reactive cells after in vitro priming. Changes in avidity of T cell receptors. / Gorczynski, Reginald M.; Rittenberg, Marvin.

In: Cellular Immunology, Vol. 16, No. 1, 1975, p. 171-181.

Research output: Contribution to journalArticle

@article{2ef89d918298476c9e4de04ab8394f29,
title = "Analysis of mixed leucocyte culture (MLC) reactive cells after in vitro priming. Changes in avidity of T cell receptors",
abstract = "Mixed leucocyte cultures were examined for populations of T cells responding to secondary stimulation with the priming antigen. Two such populations are described, one of which is stimulated optimally by low, the other by high doses of antigen. Both cell populations are sensitive to anti brain θ serum and complement, but are physically separable by size and by adherence on macrophage monolayers. The anti-brain θ-sensitive population stimulated by low antigen doses consists of larger cells with immunoglobulin-moieties on their surfaces.",
author = "Gorczynski, {Reginald M.} and Marvin Rittenberg",
year = "1975",
doi = "10.1016/0008-8749(75)90196-3",
language = "English (US)",
volume = "16",
pages = "171--181",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Analysis of mixed leucocyte culture (MLC) reactive cells after in vitro priming. Changes in avidity of T cell receptors

AU - Gorczynski, Reginald M.

AU - Rittenberg, Marvin

PY - 1975

Y1 - 1975

N2 - Mixed leucocyte cultures were examined for populations of T cells responding to secondary stimulation with the priming antigen. Two such populations are described, one of which is stimulated optimally by low, the other by high doses of antigen. Both cell populations are sensitive to anti brain θ serum and complement, but are physically separable by size and by adherence on macrophage monolayers. The anti-brain θ-sensitive population stimulated by low antigen doses consists of larger cells with immunoglobulin-moieties on their surfaces.

AB - Mixed leucocyte cultures were examined for populations of T cells responding to secondary stimulation with the priming antigen. Two such populations are described, one of which is stimulated optimally by low, the other by high doses of antigen. Both cell populations are sensitive to anti brain θ serum and complement, but are physically separable by size and by adherence on macrophage monolayers. The anti-brain θ-sensitive population stimulated by low antigen doses consists of larger cells with immunoglobulin-moieties on their surfaces.

UR - http://www.scopus.com/inward/record.url?scp=0016611594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016611594&partnerID=8YFLogxK

U2 - 10.1016/0008-8749(75)90196-3

DO - 10.1016/0008-8749(75)90196-3

M3 - Article

VL - 16

SP - 171

EP - 181

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 1

ER -