Analysis of microarray data from the macaque corpus luteum; the search for common themes in primate luteal regression

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    The factors and processes involved in regression of the primate corpus luteum (CL) are complex and not fully understood. Systemic identification of those genes that are differentially expressed utilizing macaque model systems of luteal regression could help clarify some of the important molecular events involved in loss of primate luteal structure and function during luteolysis. In addition, examining gene pathways involved in luteal regression may help elucidate novel approaches for overcoming infertility or designing ovary-based contraceptives. This review provides an overview of the current published microarray experiments evaluating the transcriptome of the macaque CL, and compares and contrasts the data from spontaneous, GnRH antagonist and prostaglandin F2α-induced luteal regression. In addition, further uses of these databases are discussed, as well as limitations of both array technology and the rhesus macaque genome array.

    Original languageEnglish (US)
    Article numbergaq080
    Pages (from-to)143-151
    Number of pages9
    JournalMolecular Human Reproduction
    Volume17
    Issue number3
    DOIs
    StatePublished - Mar 2011

    Fingerprint

    Luteolysis
    Corpus Luteum
    Macaca
    Microarray Analysis
    Primates
    Dinoprost
    Contraceptive Agents
    Macaca mulatta
    Transcriptome
    Gonadotropin-Releasing Hormone
    Infertility
    Genes
    Ovary
    Genome
    Databases
    Technology

    Keywords

    • Corpus luteum
    • Gonadotrophins
    • Microarray
    • Primate
    • Prostaglandins

    ASJC Scopus subject areas

    • Molecular Biology
    • Embryology
    • Cell Biology
    • Genetics
    • Developmental Biology
    • Reproductive Medicine
    • Obstetrics and Gynecology

    Cite this

    @article{51837dfb8ca24b1a90366f7a700a7473,
    title = "Analysis of microarray data from the macaque corpus luteum; the search for common themes in primate luteal regression",
    abstract = "The factors and processes involved in regression of the primate corpus luteum (CL) are complex and not fully understood. Systemic identification of those genes that are differentially expressed utilizing macaque model systems of luteal regression could help clarify some of the important molecular events involved in loss of primate luteal structure and function during luteolysis. In addition, examining gene pathways involved in luteal regression may help elucidate novel approaches for overcoming infertility or designing ovary-based contraceptives. This review provides an overview of the current published microarray experiments evaluating the transcriptome of the macaque CL, and compares and contrasts the data from spontaneous, GnRH antagonist and prostaglandin F2α-induced luteal regression. In addition, further uses of these databases are discussed, as well as limitations of both array technology and the rhesus macaque genome array.",
    keywords = "Corpus luteum, Gonadotrophins, Microarray, Primate, Prostaglandins",
    author = "Cecily Bishop and Bogan, {R. L.} and Jon Hennebold and Richard Stouffer",
    year = "2011",
    month = "3",
    doi = "10.1093/molehr/gaq080",
    language = "English (US)",
    volume = "17",
    pages = "143--151",
    journal = "Molecular Human Reproduction",
    issn = "1360-9947",
    publisher = "Oxford University Press",
    number = "3",

    }

    TY - JOUR

    T1 - Analysis of microarray data from the macaque corpus luteum; the search for common themes in primate luteal regression

    AU - Bishop, Cecily

    AU - Bogan, R. L.

    AU - Hennebold, Jon

    AU - Stouffer, Richard

    PY - 2011/3

    Y1 - 2011/3

    N2 - The factors and processes involved in regression of the primate corpus luteum (CL) are complex and not fully understood. Systemic identification of those genes that are differentially expressed utilizing macaque model systems of luteal regression could help clarify some of the important molecular events involved in loss of primate luteal structure and function during luteolysis. In addition, examining gene pathways involved in luteal regression may help elucidate novel approaches for overcoming infertility or designing ovary-based contraceptives. This review provides an overview of the current published microarray experiments evaluating the transcriptome of the macaque CL, and compares and contrasts the data from spontaneous, GnRH antagonist and prostaglandin F2α-induced luteal regression. In addition, further uses of these databases are discussed, as well as limitations of both array technology and the rhesus macaque genome array.

    AB - The factors and processes involved in regression of the primate corpus luteum (CL) are complex and not fully understood. Systemic identification of those genes that are differentially expressed utilizing macaque model systems of luteal regression could help clarify some of the important molecular events involved in loss of primate luteal structure and function during luteolysis. In addition, examining gene pathways involved in luteal regression may help elucidate novel approaches for overcoming infertility or designing ovary-based contraceptives. This review provides an overview of the current published microarray experiments evaluating the transcriptome of the macaque CL, and compares and contrasts the data from spontaneous, GnRH antagonist and prostaglandin F2α-induced luteal regression. In addition, further uses of these databases are discussed, as well as limitations of both array technology and the rhesus macaque genome array.

    KW - Corpus luteum

    KW - Gonadotrophins

    KW - Microarray

    KW - Primate

    KW - Prostaglandins

    UR - http://www.scopus.com/inward/record.url?scp=79951477369&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=79951477369&partnerID=8YFLogxK

    U2 - 10.1093/molehr/gaq080

    DO - 10.1093/molehr/gaq080

    M3 - Article

    VL - 17

    SP - 143

    EP - 151

    JO - Molecular Human Reproduction

    JF - Molecular Human Reproduction

    SN - 1360-9947

    IS - 3

    M1 - gaq080

    ER -