Laboratory studies have shown that certain irrigants and intracanal medicaments used in endodontic treatment have a high potential for toxicity. A clinical study was conducted to determine the effect on interappointment pain of the combined use of irrigants and medicaments with a potential for toxicity. Statistical analysis showed no significant relationship between the incidence or degree of interappointment pain and the combinations of chemical agents used during endodontic therapy. Of 245 cases treated, 76.7% were free of interappointment symptoms, 17.6% had slight pain, and 5.7% had pain that required palliative treatment.
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