Analysis of deposit depth and morphology in granular corneal dystrophy type 2 using fourier domain optical coherence tomography

Jin Pyo Hong, Tae Im Kim, Jae Lim Chung, David Huang, Hyun Soo Cho, Eung Kweon Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose:: Granular corneal dystrophy type 2 (GCD2) causes the formation of corneal deposits having 3 different morphological types. We used Fourier domain optical coherence tomography to assess the depths of each type according to the morphology. Methods:: A prospective study was performed in 54 eyes of 54 heterozygous patients with GCD2. Corneal deposits of 54 patients with GCD2 were classified into 3 morphological types: type 1, diffuse haze; type 2, granular shape (2 subgroups: type 2a, round granulated and type 2b, round spiculated); and type 3, linear shape (2 subgroups: type 3a, short side branched and type 3b, long side branched). Using Fourier domain optical coherence tomography, we measured the distances from the Bowman layer to the upper surface of the deposits (USBL), to the lower surface of the deposits (LSBL), and the thickness of the deposits (TD). The deposits formed along the flap interface were also examined among 19 patients who had LASIK. Results:: Types 1 and 2 deposits were always adjacent to the Bowman layer; thus the USBLs for each were 0.0 ± 0.0 μm, whereas that of type 3 deposits was 65.4 ± 48.0 μm (P <0.0001). The LSBL and TD of linear deposits with long side branches (type 3) (313.3 ± 71.4 and 246.2 ± 71.9 μm) were greater than those of type 1 (47.7 ± 10.2 and 47.7 ± 10.2 μm) and type 2 (91.3 ± 39.5 and 91.3 ± 39.5 μm) (P <0.0001). There were no differences in the measurements between the subgroups type 2a and type 2b or between types 3a and 3b. USBL of the laser in situ keratomileusis group was 54.5 ± 29.8 μm. Conclusions:: The depths of corneal deposits in patients with GCD2 were associated with the morphology of the deposits. The linear deposits were located most deeply in the cornea, followed by granular deposits and diffuse haze moving anteriorly. Several deposits have distinct depths according to the morphological types.

Original languageEnglish (US)
Pages (from-to)729-738
Number of pages10
JournalCornea
Volume30
Issue number7
DOIs
StatePublished - Jul 2011
Externally publishedYes

Fingerprint

Optical Coherence Tomography
Laser In Situ Keratomileusis
Cornea
Prospective Studies
Corneal dystrophy Avellino type

Keywords

  • Fourier domain optical coherence tomography
  • granular corneal dystrophy type 2
  • granular deposit
  • linear deposit

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Analysis of deposit depth and morphology in granular corneal dystrophy type 2 using fourier domain optical coherence tomography. / Hong, Jin Pyo; Kim, Tae Im; Chung, Jae Lim; Huang, David; Cho, Hyun Soo; Kim, Eung Kweon.

In: Cornea, Vol. 30, No. 7, 07.2011, p. 729-738.

Research output: Contribution to journalArticle

Hong, Jin Pyo ; Kim, Tae Im ; Chung, Jae Lim ; Huang, David ; Cho, Hyun Soo ; Kim, Eung Kweon. / Analysis of deposit depth and morphology in granular corneal dystrophy type 2 using fourier domain optical coherence tomography. In: Cornea. 2011 ; Vol. 30, No. 7. pp. 729-738.
@article{ab813a227e7046009c4507fba047f3ad,
title = "Analysis of deposit depth and morphology in granular corneal dystrophy type 2 using fourier domain optical coherence tomography",
abstract = "Purpose:: Granular corneal dystrophy type 2 (GCD2) causes the formation of corneal deposits having 3 different morphological types. We used Fourier domain optical coherence tomography to assess the depths of each type according to the morphology. Methods:: A prospective study was performed in 54 eyes of 54 heterozygous patients with GCD2. Corneal deposits of 54 patients with GCD2 were classified into 3 morphological types: type 1, diffuse haze; type 2, granular shape (2 subgroups: type 2a, round granulated and type 2b, round spiculated); and type 3, linear shape (2 subgroups: type 3a, short side branched and type 3b, long side branched). Using Fourier domain optical coherence tomography, we measured the distances from the Bowman layer to the upper surface of the deposits (USBL), to the lower surface of the deposits (LSBL), and the thickness of the deposits (TD). The deposits formed along the flap interface were also examined among 19 patients who had LASIK. Results:: Types 1 and 2 deposits were always adjacent to the Bowman layer; thus the USBLs for each were 0.0 ± 0.0 μm, whereas that of type 3 deposits was 65.4 ± 48.0 μm (P <0.0001). The LSBL and TD of linear deposits with long side branches (type 3) (313.3 ± 71.4 and 246.2 ± 71.9 μm) were greater than those of type 1 (47.7 ± 10.2 and 47.7 ± 10.2 μm) and type 2 (91.3 ± 39.5 and 91.3 ± 39.5 μm) (P <0.0001). There were no differences in the measurements between the subgroups type 2a and type 2b or between types 3a and 3b. USBL of the laser in situ keratomileusis group was 54.5 ± 29.8 μm. Conclusions:: The depths of corneal deposits in patients with GCD2 were associated with the morphology of the deposits. The linear deposits were located most deeply in the cornea, followed by granular deposits and diffuse haze moving anteriorly. Several deposits have distinct depths according to the morphological types.",
keywords = "Fourier domain optical coherence tomography, granular corneal dystrophy type 2, granular deposit, linear deposit",
author = "Hong, {Jin Pyo} and Kim, {Tae Im} and Chung, {Jae Lim} and David Huang and Cho, {Hyun Soo} and Kim, {Eung Kweon}",
year = "2011",
month = "7",
doi = "10.1097/ICO.0b013e3182000933",
language = "English (US)",
volume = "30",
pages = "729--738",
journal = "Cornea",
issn = "0277-3740",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Analysis of deposit depth and morphology in granular corneal dystrophy type 2 using fourier domain optical coherence tomography

AU - Hong, Jin Pyo

AU - Kim, Tae Im

AU - Chung, Jae Lim

AU - Huang, David

AU - Cho, Hyun Soo

AU - Kim, Eung Kweon

PY - 2011/7

Y1 - 2011/7

N2 - Purpose:: Granular corneal dystrophy type 2 (GCD2) causes the formation of corneal deposits having 3 different morphological types. We used Fourier domain optical coherence tomography to assess the depths of each type according to the morphology. Methods:: A prospective study was performed in 54 eyes of 54 heterozygous patients with GCD2. Corneal deposits of 54 patients with GCD2 were classified into 3 morphological types: type 1, diffuse haze; type 2, granular shape (2 subgroups: type 2a, round granulated and type 2b, round spiculated); and type 3, linear shape (2 subgroups: type 3a, short side branched and type 3b, long side branched). Using Fourier domain optical coherence tomography, we measured the distances from the Bowman layer to the upper surface of the deposits (USBL), to the lower surface of the deposits (LSBL), and the thickness of the deposits (TD). The deposits formed along the flap interface were also examined among 19 patients who had LASIK. Results:: Types 1 and 2 deposits were always adjacent to the Bowman layer; thus the USBLs for each were 0.0 ± 0.0 μm, whereas that of type 3 deposits was 65.4 ± 48.0 μm (P <0.0001). The LSBL and TD of linear deposits with long side branches (type 3) (313.3 ± 71.4 and 246.2 ± 71.9 μm) were greater than those of type 1 (47.7 ± 10.2 and 47.7 ± 10.2 μm) and type 2 (91.3 ± 39.5 and 91.3 ± 39.5 μm) (P <0.0001). There were no differences in the measurements between the subgroups type 2a and type 2b or between types 3a and 3b. USBL of the laser in situ keratomileusis group was 54.5 ± 29.8 μm. Conclusions:: The depths of corneal deposits in patients with GCD2 were associated with the morphology of the deposits. The linear deposits were located most deeply in the cornea, followed by granular deposits and diffuse haze moving anteriorly. Several deposits have distinct depths according to the morphological types.

AB - Purpose:: Granular corneal dystrophy type 2 (GCD2) causes the formation of corneal deposits having 3 different morphological types. We used Fourier domain optical coherence tomography to assess the depths of each type according to the morphology. Methods:: A prospective study was performed in 54 eyes of 54 heterozygous patients with GCD2. Corneal deposits of 54 patients with GCD2 were classified into 3 morphological types: type 1, diffuse haze; type 2, granular shape (2 subgroups: type 2a, round granulated and type 2b, round spiculated); and type 3, linear shape (2 subgroups: type 3a, short side branched and type 3b, long side branched). Using Fourier domain optical coherence tomography, we measured the distances from the Bowman layer to the upper surface of the deposits (USBL), to the lower surface of the deposits (LSBL), and the thickness of the deposits (TD). The deposits formed along the flap interface were also examined among 19 patients who had LASIK. Results:: Types 1 and 2 deposits were always adjacent to the Bowman layer; thus the USBLs for each were 0.0 ± 0.0 μm, whereas that of type 3 deposits was 65.4 ± 48.0 μm (P <0.0001). The LSBL and TD of linear deposits with long side branches (type 3) (313.3 ± 71.4 and 246.2 ± 71.9 μm) were greater than those of type 1 (47.7 ± 10.2 and 47.7 ± 10.2 μm) and type 2 (91.3 ± 39.5 and 91.3 ± 39.5 μm) (P <0.0001). There were no differences in the measurements between the subgroups type 2a and type 2b or between types 3a and 3b. USBL of the laser in situ keratomileusis group was 54.5 ± 29.8 μm. Conclusions:: The depths of corneal deposits in patients with GCD2 were associated with the morphology of the deposits. The linear deposits were located most deeply in the cornea, followed by granular deposits and diffuse haze moving anteriorly. Several deposits have distinct depths according to the morphological types.

KW - Fourier domain optical coherence tomography

KW - granular corneal dystrophy type 2

KW - granular deposit

KW - linear deposit

UR - http://www.scopus.com/inward/record.url?scp=79959210676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959210676&partnerID=8YFLogxK

U2 - 10.1097/ICO.0b013e3182000933

DO - 10.1097/ICO.0b013e3182000933

M3 - Article

VL - 30

SP - 729

EP - 738

JO - Cornea

JF - Cornea

SN - 0277-3740

IS - 7

ER -