Analysis of behavioural responses to an ACTH analog in CXB/By recombinant inbred mice

John C. Crabbe, Henk Rigter, Sjeng Kerbusch

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Male mice of the C57BL/6By and BALB/cBy inbred strains, their reciprocal F1 hybrids, and 7 recombinant inbred strains, were tested for open-field activity, a shock-motivated successive reversal position discrimination problem in a T-maze, and a toggle box exploration task. The test battery was repeated one month later. Finally, mice were tested for the acquisition and extinction of a taste aversion conditioned by ethanol injection. Mice of each strain were tested after injection with saline or one of 3 doses of an ACTH analogue. Highly significant genotypic differences were found for all measures, an expected result. The strain distribution pattern seen in the toggle box suggested single gene mediation of exploratory activity after habituation. One aspect of avoidance responding and extinction of conditioned taste aversion also yielded strain distribution pattern consistent with single gene control. Peptide treatment reduced internal field crossings in the open field. This effect was not strain dependent. Peptide treatment had no effect on T-maze learning, conditioned taste aversion, or toggle-box exploration.

Original languageEnglish (US)
Pages (from-to)289-314
Number of pages26
JournalBehavioural Brain Research
Volume4
Issue number3
DOIs
StatePublished - Mar 1982

Keywords

  • ACTH analogue
  • avoidance
  • conditioned taste aversion
  • discrimination learning
  • ethanol
  • exploratory activity
  • habituation
  • mouse
  • open field activity
  • recombinant inbred strains

ASJC Scopus subject areas

  • Behavioral Neuroscience

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