Analysis of a new class I gene mapping to the Hmt region of the mouse

Kurt A. Brorson, Carolyn (Sue) Richards, Stephen W. Hunt, Hilde Cheroutre, Kirsten Fischer Lindahl, Leroy Hood

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The major histocompatibility complex (MHC) of the BALB/c mouse contains three genes encoding classical class I molecules, as well as at least 32 nonclassical class I genes. Although much is known about the genes encoding the classical class I molecules, the majority of the nonclassical genes have not been characterized. This report describes a newly identified nonclassical class I gene, Thy19.4, which contains an open reading frame and resembles in several regards the genes encoding classical class I molecules. The similarities include shared amino acid sequence motifs which suggest that the putative Thy19.4 molecule may assume a tertiary structure similar to that of the classical class I molecules, as well as widespread transcription in a variety of tissues. However, unlike the classical class I genes, the Thy19.4 gene maps approximately 1 cm distal to the Tla region of the MHC, in the same region as the gene encoding the Hmt element of the maternally transmitted antigen.

Original languageEnglish (US)
Pages (from-to)273-283
Number of pages11
JournalImmunogenetics
Volume30
Issue number4
DOIs
StatePublished - Oct 1989
Externally publishedYes

Fingerprint

MHC Class I Genes
Chromosome Mapping
Genes
Major Histocompatibility Complex
Amino Acid Motifs
Open Reading Frames
Amino Acid Sequence
Antigens

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Brorson, K. A., Richards, C. S., Hunt, S. W., Cheroutre, H., Lindahl, K. F., & Hood, L. (1989). Analysis of a new class I gene mapping to the Hmt region of the mouse. Immunogenetics, 30(4), 273-283. https://doi.org/10.1007/BF02421331

Analysis of a new class I gene mapping to the Hmt region of the mouse. / Brorson, Kurt A.; Richards, Carolyn (Sue); Hunt, Stephen W.; Cheroutre, Hilde; Lindahl, Kirsten Fischer; Hood, Leroy.

In: Immunogenetics, Vol. 30, No. 4, 10.1989, p. 273-283.

Research output: Contribution to journalArticle

Brorson, KA, Richards, CS, Hunt, SW, Cheroutre, H, Lindahl, KF & Hood, L 1989, 'Analysis of a new class I gene mapping to the Hmt region of the mouse', Immunogenetics, vol. 30, no. 4, pp. 273-283. https://doi.org/10.1007/BF02421331
Brorson, Kurt A. ; Richards, Carolyn (Sue) ; Hunt, Stephen W. ; Cheroutre, Hilde ; Lindahl, Kirsten Fischer ; Hood, Leroy. / Analysis of a new class I gene mapping to the Hmt region of the mouse. In: Immunogenetics. 1989 ; Vol. 30, No. 4. pp. 273-283.
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