Analysis of 100 high-coverage genomes from a pedigreed captive baboon colony

Jacqueline A. Robinson, Saurabh Belsare, Shifra Birnbaum, Deborah E. Newman, Jeannie Chan, Jeremy P. Glenn, Betsy Ferguson, Laura A. Cox, Jeffrey D. Wall

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations


    Baboons (genus Papio) are broadly studied in the wild and in captivity. They are widely used as a nonhuman primate model for biomedical studies, and the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute has maintained a large captive baboon colony for more than 50 yr. Unlike other model organisms, however, the genomic resources for baboons are severely lacking. This has hindered the progress of studies using baboons as a model for basic biology or human disease. Here, we describe a data set of 100 high-coverage whole-genome sequences obtained from the mixed colony of olive (P. anubis) and yellow (P. cynocephalus) baboons housed at the SNPRC. These data provide a comprehensive catalog of common genetic variation in baboons, as well as a fine-scale genetic map. We show how the data can be used to learn about ancestry and admixture and to correct errors in the colony records. Finally, we investigated the consequences of inbreeding within the SNPRC colony and found clear evidence for increased rates of infant mortality and increased homozygosity of putatively deleterious alleles in inbred individuals.

    Original languageEnglish (US)
    Pages (from-to)848-856
    Number of pages9
    JournalGenome Research
    Issue number5
    StatePublished - May 2019

    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)


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