An update on the genetics of HLA B27-associated acute anterior uveitis

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The discovery of the association of HLA B27 with spondyloarthropathy led to more questions than answers about the role of this gene in disease susceptibility. The realization that HLA B27 was not responsible for all of the genetic effects helped to lay a foundation for further investigation into the genetics of uveitis. Over several decades, genetic findings have provided clues to advance the understanding of mechanisms of uveitis and to catalyze new research on diagnostics, animal models, and therapies. From the early candidate gene studies on immune mediators to the recent genome-wide investigations, much has been discovered. However, these discoveries have come with the caveat that a genetic finding does not automatically reveal the disease-relevant functional effect of the associated variant.

Original languageEnglish (US)
Pages (from-to)108-114
Number of pages7
JournalOcular Immunology and Inflammation
Volume19
Issue number2
DOIs
StatePublished - Apr 2011

Fingerprint

Anterior Uveitis
HLA-B27 Antigen
Uveitis
Spondylarthropathies
Disease Susceptibility
Genes
Animal Models
Genome
Research
Therapeutics

Keywords

  • genetics
  • HLA
  • polymorphisms
  • spondyloarthropathy
  • uveitis

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy

Cite this

An update on the genetics of HLA B27-associated acute anterior uveitis. / Martin, Tammy; Rosenbaum, James (Jim).

In: Ocular Immunology and Inflammation, Vol. 19, No. 2, 04.2011, p. 108-114.

Research output: Contribution to journalArticle

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