An overview of the use of the monoclonal antibody OKT3 in renal transplantation

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The murine monoclonal anti-T cell antibody, OKT3, has been used during the past 6 years in various clinical transplantation studies. Undoubtedly it has proved to be the most effective and specific immunosuppressive drug widely available for use in organ transplantation. However, because of problems of first-dose symptoms, recurrent rejection, and antibody production, currently used protocols with OKT3 might not be the final answer in immunosuppressive therapy. OKT3 is an important prototype of future monoclonal antibodies and can be considered the gold standard against which newer drugs must be compared.

Original languageEnglish (US)
Pages (from-to)1248-1252
Number of pages5
JournalTransplantation Proceedings
Volume20
Issue number6
StatePublished - 1988

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Muromonab-CD3
Kidney Transplantation
Immunosuppressive Agents
Organ Transplantation
Pharmaceutical Preparations
Antibody Formation
Transplantation
Monoclonal Antibodies
T-Lymphocytes
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

An overview of the use of the monoclonal antibody OKT3 in renal transplantation. / Norman, Douglas.

In: Transplantation Proceedings, Vol. 20, No. 6, 1988, p. 1248-1252.

Research output: Contribution to journalArticle

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