An oral cavity carcinoma nomogram to predict benefit of adjuvant radiotherapy

Samuel Wang, Snehal G. Patel, Jatin P. Shah, David P. Goldstein, Jonathan C. Irish, Andre L. Carvalho, Luiz P. Kowalski, Jennifer L. Lockhart, John Holland, Neil D. Gross

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Importance: After surgical resection for oral cavity squamous cell carcinoma, adjuvant radiotherapy may be recommended for patients at higher risk for locoregional recurrence, but it can be difficult to predict whether a particular patient will benefit. Objective: To construct a model to predict which patients with oral cavity squamous cell carcinoma would benefit from adjuvant radiotherapy. Design and Setting: We constructed several types of survival models using a set of 979 patients with oral cavity squamous cell carcinoma. Covariates were age, sex, tobacco use, stage, grade, margins, and subsite. The best performing model was externally validated on a set of 431 patients. Participants: The model was based on a set of 979 patients with oral cavity squamous cell carcinoma, including 563 from Memorial Sloan Kettering Cancer Center, New York, New York, and 416 from the Hospital AC Camargo, São Paulo, Brazil. The validation set consisted of 431 patients from Princess Margaret Hospital, Toronto, Ontario, Canada. Main Outcome and Measure: The primary outcome measure of interest was locoregional recurrence-free survival. Results: The lognormal model showed the best performance per the Akaike information criterion. An online nomogram was built from this model that estimates locoregional failure-free survival with and without postoperative radiotherapy. Conclusions and Relevance: A web-based nomogram can be used as a decision aid for adjuvant treatment decisions for patients with oral cavity squamous cell carcinoma.

Original languageEnglish (US)
Pages (from-to)554-559
Number of pages6
JournalJAMA Otolaryngology - Head and Neck Surgery
Volume139
Issue number6
DOIs
StatePublished - Jun 2013

Fingerprint

Nomograms
Adjuvant Radiotherapy
Mouth
Carcinoma
Squamous Cell Carcinoma
Survival
Outcome Assessment (Health Care)
Recurrence
Decision Support Techniques
Tobacco Use
Ontario
Canada
Brazil
Radiotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Wang, S., Patel, S. G., Shah, J. P., Goldstein, D. P., Irish, J. C., Carvalho, A. L., ... Gross, N. D. (2013). An oral cavity carcinoma nomogram to predict benefit of adjuvant radiotherapy. JAMA Otolaryngology - Head and Neck Surgery, 139(6), 554-559. https://doi.org/10.1001/jamaoto.2013.3001

An oral cavity carcinoma nomogram to predict benefit of adjuvant radiotherapy. / Wang, Samuel; Patel, Snehal G.; Shah, Jatin P.; Goldstein, David P.; Irish, Jonathan C.; Carvalho, Andre L.; Kowalski, Luiz P.; Lockhart, Jennifer L.; Holland, John; Gross, Neil D.

In: JAMA Otolaryngology - Head and Neck Surgery, Vol. 139, No. 6, 06.2013, p. 554-559.

Research output: Contribution to journalArticle

Wang, S, Patel, SG, Shah, JP, Goldstein, DP, Irish, JC, Carvalho, AL, Kowalski, LP, Lockhart, JL, Holland, J & Gross, ND 2013, 'An oral cavity carcinoma nomogram to predict benefit of adjuvant radiotherapy', JAMA Otolaryngology - Head and Neck Surgery, vol. 139, no. 6, pp. 554-559. https://doi.org/10.1001/jamaoto.2013.3001
Wang, Samuel ; Patel, Snehal G. ; Shah, Jatin P. ; Goldstein, David P. ; Irish, Jonathan C. ; Carvalho, Andre L. ; Kowalski, Luiz P. ; Lockhart, Jennifer L. ; Holland, John ; Gross, Neil D. / An oral cavity carcinoma nomogram to predict benefit of adjuvant radiotherapy. In: JAMA Otolaryngology - Head and Neck Surgery. 2013 ; Vol. 139, No. 6. pp. 554-559.
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