An open label pilot study of transcranial magnetic stimulation for pregnant women with major depressive disorder

Deborah R. Kim, Neill Epperson, Emmanuelle Pare, Juan M. Gonzalez, Samuel Parry, Michael E. Thase, Pilar Cristancho, Mary D. Sammel, John P. O'Reardon

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective: Despite the data that major depressive disorder (MDD) is common during pregnancy and that pregnant women prefer nonmedication treatment options, there is a paucity of research examining alternative treatments for this special population. We present the results of an open label pilot study examining treatment with transcranial magnetic stimulation (TMS) in pregnant women with MDD. Methods: Ten women with MDD in the second or third trimester of pregnancy were treated with 20 sessions of 1-Hz TMS at 100% of motor threshold (MT) to the right dorsolateral prefrontal cortex. The total study dose was 6000 pulses. Antenatal monitoring was performed during treatment sessions 1, 10, and 20. Results: Seven of ten (70%) subjects responded (decrease ≥50% in Hamilton Depression Rating Scale [HDRS-17] scores). No adverse pregnancy or fetal outcomes were observed. All infants were admitted to the well baby nursery and were discharged with the mother. Mild headache was the only common adverse event and was reported by 4 of 10 (40%) subjects. Conclusions: TMS appears to be a promising treatment option for pregnant women who do not wish to take antidepressant medications.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalJournal of Women's Health
Volume20
Issue number2
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

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Transcranial Magnetic Stimulation
Major Depressive Disorder
Pregnant Women
Pregnancy
Therapeutics
Nurseries
Third Pregnancy Trimester
Second Pregnancy Trimester
Prefrontal Cortex
Antidepressive Agents
Headache
Mothers
Depression
Research
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

An open label pilot study of transcranial magnetic stimulation for pregnant women with major depressive disorder. / Kim, Deborah R.; Epperson, Neill; Pare, Emmanuelle; Gonzalez, Juan M.; Parry, Samuel; Thase, Michael E.; Cristancho, Pilar; Sammel, Mary D.; O'Reardon, John P.

In: Journal of Women's Health, Vol. 20, No. 2, 01.02.2011, p. 255-261.

Research output: Contribution to journalArticle

Kim, DR, Epperson, N, Pare, E, Gonzalez, JM, Parry, S, Thase, ME, Cristancho, P, Sammel, MD & O'Reardon, JP 2011, 'An open label pilot study of transcranial magnetic stimulation for pregnant women with major depressive disorder', Journal of Women's Health, vol. 20, no. 2, pp. 255-261. https://doi.org/10.1089/jwh.2010.2353
Kim, Deborah R. ; Epperson, Neill ; Pare, Emmanuelle ; Gonzalez, Juan M. ; Parry, Samuel ; Thase, Michael E. ; Cristancho, Pilar ; Sammel, Mary D. ; O'Reardon, John P. / An open label pilot study of transcranial magnetic stimulation for pregnant women with major depressive disorder. In: Journal of Women's Health. 2011 ; Vol. 20, No. 2. pp. 255-261.
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