An investigation into the association between liver damage and metastatic uveal melanoma

Steven G. Pascal, Amanda M. Saulenas, George A. Fournier, Johanna M. Seddon, R. Mark Hatfield, Daniel M. Albert

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We examined the effect of liver damage induced by carbon tetrachloride on the incidence of hepatic metastasis in the Greene hamster melanoma. Nine of 17 animals with liver damage had melanoma growth in the liver after the intraportal vein injection of tumor cells, whereas tumor growth occurred in four of 27 control animals (P 〈 .01). These results suggest that, in this model, liver damage predisposes to metastatic involvement by melanoma.

Original languageEnglish (US)
Pages (from-to)448-453
Number of pages6
JournalAmerican journal of ophthalmology
Volume100
Issue number3
DOIs
StatePublished - Sep 15 1985

ASJC Scopus subject areas

  • Ophthalmology

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