An investigation into the association between liver damage and metastatic uveal melanoma

Steven G. Pascal; Amanda M. Saulenas; George A. Fournier; Johanna M. Seddon; R. Mark Hatfield; Daniel M. Albert

doi:10.1016/0002-9394(85)90512-4

An investigation into the association between liver damage and metastatic uveal melanoma

Steven G. Pascal, Amanda M. Saulenas, George A. Fournier, Johanna M. Seddon, R. Mark Hatfield, Daniel M. Albert

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We examined the effect of liver damage induced by carbon tetrachloride on the incidence of hepatic metastasis in the Greene hamster melanoma. Nine of 17 animals with liver damage had melanoma growth in the liver after the intraportal vein injection of tumor cells, whereas tumor growth occurred in four of 27 control animals (P 〈 .01). These results suggest that, in this model, liver damage predisposes to metastatic involvement by melanoma.

Original language	English (US)
Pages (from-to)	448-453
Number of pages	6
Journal	American journal of ophthalmology
Volume	100
Issue number	3
DOIs	https://doi.org/10.1016/0002-9394(85)90512-4
State	Published - Sep 15 1985
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/0002-9394(85)90512-4

Cite this

@article{f9b7927ef6b74be5a995514da9e7d784,

title = "An investigation into the association between liver damage and metastatic uveal melanoma",

abstract = "We examined the effect of liver damage induced by carbon tetrachloride on the incidence of hepatic metastasis in the Greene hamster melanoma. Nine of 17 animals with liver damage had melanoma growth in the liver after the intraportal vein injection of tumor cells, whereas tumor growth occurred in four of 27 control animals (P 〈 .01). These results suggest that, in this model, liver damage predisposes to metastatic involvement by melanoma.",

author = "Pascal, {Steven G.} and Saulenas, {Amanda M.} and Fournier, {George A.} and Seddon, {Johanna M.} and Hatfield, {R. Mark} and Albert, {Daniel M.}",

note = "Funding Information: From the Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts. This study was supported in part by grant EY01917 from the National Institute of Health (Dr. Albert). Presented in part before the Association for Research in Vision and Ophthalmology, Sarasota, Florida, May 9, 1985.",

year = "1985",

month = sep,

day = "15",

doi = "10.1016/0002-9394(85)90512-4",

language = "English (US)",

volume = "100",

pages = "448--453",

journal = "American journal of ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

number = "3",

}

TY - JOUR

T1 - An investigation into the association between liver damage and metastatic uveal melanoma

AU - Pascal, Steven G.

AU - Saulenas, Amanda M.

AU - Fournier, George A.

AU - Seddon, Johanna M.

AU - Hatfield, R. Mark

AU - Albert, Daniel M.

N1 - Funding Information: From the Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts. This study was supported in part by grant EY01917 from the National Institute of Health (Dr. Albert). Presented in part before the Association for Research in Vision and Ophthalmology, Sarasota, Florida, May 9, 1985.

PY - 1985/9/15

Y1 - 1985/9/15

N2 - We examined the effect of liver damage induced by carbon tetrachloride on the incidence of hepatic metastasis in the Greene hamster melanoma. Nine of 17 animals with liver damage had melanoma growth in the liver after the intraportal vein injection of tumor cells, whereas tumor growth occurred in four of 27 control animals (P 〈 .01). These results suggest that, in this model, liver damage predisposes to metastatic involvement by melanoma.

AB - We examined the effect of liver damage induced by carbon tetrachloride on the incidence of hepatic metastasis in the Greene hamster melanoma. Nine of 17 animals with liver damage had melanoma growth in the liver after the intraportal vein injection of tumor cells, whereas tumor growth occurred in four of 27 control animals (P 〈 .01). These results suggest that, in this model, liver damage predisposes to metastatic involvement by melanoma.

UR - http://www.scopus.com/inward/record.url?scp=0022005343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022005343&partnerID=8YFLogxK

U2 - 10.1016/0002-9394(85)90512-4

DO - 10.1016/0002-9394(85)90512-4

M3 - Article

C2 - 4037035

AN - SCOPUS:0022005343

SN - 0002-9394

VL - 100

SP - 448

EP - 453

JO - American journal of ophthalmology

JF - American journal of ophthalmology

IS - 3

ER -

An investigation into the association between liver damage and metastatic uveal melanoma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this