An intracerebral, physiological role for angiotensin: Effects of central blockade

Virginia Brooks, R. L. Malvin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Although exogenous angiotensin II (AII) exerts a multitude of effects on the central nervous system, there is little evidence supporting a physiological role for the endogenously produced peptide. Some investigators have tested the hypothesis that AII is physiologically active in the brain with intracerebral infusions of blockers of the renin-angiotensin system. If blocker infusions produce effects that are opposite to exogenous AII infusions, it is evidence supporting a physiological role for endogenously generated angiotensin. Previous work has demonstrated that intraventricular infusion of AII elicits thirst and stimulates antidiuretic hormone and ACTH release. Intracerebral administration of AII also suppresses aldosterone secretion. Experiments that employed the blockers saralasin, a competitive inhibitor of AII, and SQ 20881, a converting enzyme blocker, are presented; results suggest that endogenous AII is involved in the control of thirst and peripheral hormone levels. Infusion of the blockers in the ventricular system led to changes in peripheral hormone concentrations opposite to that observed following infusions of AII.

Original languageEnglish (US)
Pages (from-to)2272-2275
Number of pages4
JournalFederation Proceedings
Volume38
Issue number9
StatePublished - 1979
Externally publishedYes

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Angiotensins
Angiotensin II
Thirst
Teprotide
Hormones
Saralasin
Intraventricular Infusions
Renin-Angiotensin System
Aldosterone
Vasopressins
Adrenocorticotropic Hormone
Central Nervous System
Research Personnel
Peptides
Brain
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

An intracerebral, physiological role for angiotensin : Effects of central blockade. / Brooks, Virginia; Malvin, R. L.

In: Federation Proceedings, Vol. 38, No. 9, 1979, p. 2272-2275.

Research output: Contribution to journalArticle

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