Abstract
We generated a rhesus macaque induced pluripotent stem cell (riPSC) line, riPSC89, from rhesus embryonic fibroblasts (REFs). Fibroblasts were expanded from the skin of a rhesus macaque embryo at embryonic day 47. REFs and riPSCs had a normal male (42, XY) karyotype. The riPSC89 line was positive for markers of self-renewal including OCT4, NANOG, TRA-1-81 and SSEA4. Pluripotency was demonstrated through the generation of teratomas using transplantation into immunocompromised mice. The riPSC89 line may be a useful non-human primate resource to uncover developmental origins of disease, or used as a basic model to understand lineage specification in the primate embryo.
Original language | English (US) |
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Pages (from-to) | 444-447 |
Number of pages | 4 |
Journal | Stem Cell Research |
Volume | 17 |
Issue number | 2 |
DOIs | |
State | Published - Sep 2016 |
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology