An integrated view of cisplatin-induced nephrotoxicity and ototoxicity

Takatoshi Karasawa, Peter S. Steyger

Research output: Contribution to journalReview article

168 Scopus citations

Abstract

Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and ototoxic side-effects remain major clinical limitations. Recent studies have improved our understanding of the molecular mechanisms of cisplatin-induced nephrotoxicity and ototoxicity. While cisplatin binding to DNA is the major cytotoxic mechanism in proliferating (cancer) cells, nephrotoxicity and ototoxicity appear to result from toxic levels of reactive oxygen species and protein dysregulation within various cellular compartments. In this review, we discuss molecular mechanisms of cisplatin-induced nephrotoxicity and ototoxicity. We also discuss potential clinical strategies to prevent nephrotoxicity and ototoxicity and their current limitations.

Original languageEnglish (US)
Pages (from-to)219-227
Number of pages9
JournalToxicology Letters
Volume237
Issue number3
DOIs
StatePublished - Sep 7 2015

Keywords

  • Cisplatin
  • Intracellular mechanisms
  • Nephrotoxicity
  • Ototoxicity

ASJC Scopus subject areas

  • Toxicology

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