Abstract
The disordered SIRT1 N-terminal region contains an insulin-responsive sensor (IRS), comprising an acidic cluster (AC) and a 3-helix bundle (3HB), controlling enzyme activity. Insulin triggers DBC1 and PACS-2 binding to the IRS. DBC1 removes the protective shield that hides the IRS, enabling PACS-2 to bind the acidic cluster and the 3-helix bundle, inhibiting SIRT1.
Original language | English (US) |
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Pages (from-to) | 985-998.e7 |
Journal | Molecular Cell |
Volume | 72 |
Issue number | 6 |
DOIs | |
State | Published - Dec 20 2018 |
Keywords
- 3-helix bundle
- AKT
- FGF21
- NMR spectroscopy
- PACS2
- PGC-1alpha
- PPARalpha
- STACs
- diet-induced obesity
- liver
- nuclear magnetic resonance spectroscopy
- small molecule sirtuin-activating compounds
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology