TY - JOUR
T1 - An innately dangerous balancing act
T2 - Intestinal homeostasis, inflammation, and colitis-associated cancer
AU - Asquith, Mark
AU - Powrie, Fiona
PY - 2010/8/2
Y1 - 2010/8/2
N2 - Inflammatory bowel disease (IBD) is characterized by dysregulated immune responses to the intestinal microbiota, and by chronic intestinal inflammation. Several recent studies demonstrate the importance of innate microbial recognition by immune and nonimmune cells in the gut. Paradoxically, either diminished or exacerbated innate immune signaling may trigger the breakdown of intestinal homeostasis, leading to IBD and colitis-associated cancer (CAC). This dichotomy may reflect divergent functional roles for immune sensing in intestinal epithelial cells and leukocytes, which may vary with distinct disease mechanisms.
AB - Inflammatory bowel disease (IBD) is characterized by dysregulated immune responses to the intestinal microbiota, and by chronic intestinal inflammation. Several recent studies demonstrate the importance of innate microbial recognition by immune and nonimmune cells in the gut. Paradoxically, either diminished or exacerbated innate immune signaling may trigger the breakdown of intestinal homeostasis, leading to IBD and colitis-associated cancer (CAC). This dichotomy may reflect divergent functional roles for immune sensing in intestinal epithelial cells and leukocytes, which may vary with distinct disease mechanisms.
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U2 - 10.1084/jem.20101330
DO - 10.1084/jem.20101330
M3 - Short survey
C2 - 20679404
AN - SCOPUS:77955383804
SN - 0022-1007
VL - 207
SP - 1573
EP - 1577
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 8
ER -