An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci

Jeffrey Rogers, Roy Garcia, Wendy Shelledy, Jordan Kaplan, Ann Arya, Zach Johnson, MacKenzie Bergstrom, Leilah Novakowski, Prakash Nair, Amanda Vinson, Deborah Newman, Gary Heckman, Judy Cameron

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primate species in biomedical research. To create new opportunities for genetic and genomic studies using rhesus monkeys, we constructed a genetic linkage map of the rhesus genome. This map consists of 241 microsatellite loci, all previously mapped in the human genome. These polymorphisms were genotyped in five pedigrees of rhesus monkeys totaling 865 animals. The resulting linkage map covers 2048 cM including all 20 rhesus autosomes, with average spacing between markers of 9.3 cM. Average heterozygosity among those markers is 0.73. This linkage map provides new comparative information concerning locus order and interlocus distances in humans and rhesus monkeys. The map will facilitate whole-genome linkage screens to locate quantitative trait loci (QTLs) that influence individual variation in phenotypic traits related to basic primate anatomy, physiology, and behavior, as well as QTLs relevant to risk factors for human disease.

Original languageEnglish (US)
Pages (from-to)30-38
Number of pages9
JournalGenomics
Volume87
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

Fingerprint

Genetic Linkage
Human Genome
Macaca mulatta
Microsatellite Repeats
Quantitative Trait Loci
Primates
Genome
Pedigree
Biomedical Research
Anatomy

Keywords

  • Genetic linkage
  • Linkage mapping
  • Macaque
  • Microsatellite
  • Recombination
  • Rhesus monkey

ASJC Scopus subject areas

  • Genetics

Cite this

Rogers, J., Garcia, R., Shelledy, W., Kaplan, J., Arya, A., Johnson, Z., ... Cameron, J. (2006). An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci. Genomics, 87(1), 30-38. https://doi.org/10.1016/j.ygeno.2005.10.004

An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci. / Rogers, Jeffrey; Garcia, Roy; Shelledy, Wendy; Kaplan, Jordan; Arya, Ann; Johnson, Zach; Bergstrom, MacKenzie; Novakowski, Leilah; Nair, Prakash; Vinson, Amanda; Newman, Deborah; Heckman, Gary; Cameron, Judy.

In: Genomics, Vol. 87, No. 1, 01.2006, p. 30-38.

Research output: Contribution to journalArticle

Rogers, J, Garcia, R, Shelledy, W, Kaplan, J, Arya, A, Johnson, Z, Bergstrom, M, Novakowski, L, Nair, P, Vinson, A, Newman, D, Heckman, G & Cameron, J 2006, 'An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci', Genomics, vol. 87, no. 1, pp. 30-38. https://doi.org/10.1016/j.ygeno.2005.10.004
Rogers, Jeffrey ; Garcia, Roy ; Shelledy, Wendy ; Kaplan, Jordan ; Arya, Ann ; Johnson, Zach ; Bergstrom, MacKenzie ; Novakowski, Leilah ; Nair, Prakash ; Vinson, Amanda ; Newman, Deborah ; Heckman, Gary ; Cameron, Judy. / An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci. In: Genomics. 2006 ; Vol. 87, No. 1. pp. 30-38.
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