An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory

Hyejin Kang, Linus D. Sun, Coleen M. Atkins, Thomas R. Soderling, Matthew A. Wilson, Susumu Tonegawa

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    Abstract

    Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been implicated in the regulation of CRE-dependent transcription. To investigate the role of this kinase in neuronal plasticity and memory, we generated transgenic mice in which the expression of a dominant-negative form of CaMKIV (dnCaMKIV) is restricted to the postnatal forebrain. In these transgenic mice, activity-induced CREB phosphorylation and c-Fos expression were significantly attenuated. Hippocampal late LTP (L-LTP) was also impaired, whereas basic synaptic function and early LTP (E-LTP) were unaffected. These deficits correlated with impairments in long-term memory, specifically in its consolidation/retention phase but not in the acquisition phase. These results indicate that neural activity-dependent CaMKIV signaling in the neuronal nucleus plays an important role in the consolidation/retention of hippocampus-dependent long-term memory.

    Original languageEnglish (US)
    Pages (from-to)771-783
    Number of pages13
    JournalCell
    Volume106
    Issue number6
    DOIs
    StatePublished - Sep 21 2001

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    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Kang, H., Sun, L. D., Atkins, C. M., Soderling, T. R., Wilson, M. A., & Tonegawa, S. (2001). An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Cell, 106(6), 771-783. https://doi.org/10.1016/S0092-8674(01)00497-4