Objective: To estimate the effect of oral midazolam on patient pain and anxiety perception during first-trimester surgical abortion. Methods: Between May and December 2013, we conducted a randomized, double-blind, placebo-controlled trial. Patients between 6 0/7 and 10 6/7 weeks of gestation received 10 mg oral midazolam or placebo 30-60 minutes before surgical abortion. All patients received ibuprofen and a paracervical block. We powered the study (power80%; significance level.025) to detect a 15-mm difference in our two a priori primary outcomes of pain and anxiety with uterine aspiration on a 100-mm visual analog scale. Secondary outcomes were pain and anxiety at additional time points, memory, satisfaction, side effects, and adverse events. Results: Demographics were similar between groups (placebo62, midazolam62). Compared with those randomized to placebo, patients who received midazolam had significantly less anxiety preoperatively (room entry: 51.4 mm compared with 34.5 mm, P
ASJC Scopus subject areas
- Obstetrics and Gynecology
An Evaluation of Oral Midazolam for Anxiety and Pain in First-Trimester Surgical Abortion : A Randomized Controlled Trial. / Bayer, Lisa L.; Edelman, Alison; Fu, Rongwei (Rochelle); Lambert, William; Nichols, Mark D.; Bednarek, Paula; Miller, Kelsey; Jensen, Jeffrey.In: Obstetrics and Gynecology, Vol. 126, No. 1, 23.07.2015, p. 37-46.
Research output: Contribution to journal › Article