An Epidemic of Dengue-1 in a Remote Village in Rural Laos

Audrey Dubot-Pérès, Phengta Vongphrachanh, Justin Denny, Rattanaphone Phetsouvanh, Singharath Linthavong, Bounthanom Sengkeopraseuth, Amphai Khasing, Vimattha Xaythideth, Catrin E. Moore, Manivanh Vongsouvath, Josée Castonguay-Vanier, Bountoy Sibounheuang, Thaksinaporn Taojaikong, Anisone Chanthongthip, Xavier de Lamballerie, Paul N. Newton

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In the Lao PDR (Laos), urban dengue is an increasingly recognised public health problem. We describe a dengue-1 virus outbreak in a rural northwestern Lao forest village during the cool season of 2008. The isolated strain was genotypically "endemic" and not "sylvatic," belonging to the genotype 1, Asia 3 clade. Phylogenetic analyses of 37 other dengue-1 sequences from diverse areas of Laos between 2007 and 2010 showed that the geographic distribution of some strains remained focal overtime while others were dispersed throughout the country. Evidence that dengue viruses have broad circulation in the region, crossing country borders, was also obtained. Whether the outbreak arose from dengue importation from an urban centre into a dengue-naïve community or crossed into the village from a forest cycle is unknown. More epidemiological and entomological investigations are required to understand dengue epidemiology and the importance of rural and forest dengue dynamics in Laos.

Original languageEnglish (US)
Article numbere2360
JournalPLoS Neglected Tropical Diseases
Volume7
Issue number8
DOIs
StatePublished - Aug 2013
Externally publishedYes

Fingerprint

Laos
Dengue
Dengue Virus
Disease Outbreaks
Emigration and Immigration
Epidemiology
Public Health
Genotype
Forests

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Dubot-Pérès, A., Vongphrachanh, P., Denny, J., Phetsouvanh, R., Linthavong, S., Sengkeopraseuth, B., ... Newton, P. N. (2013). An Epidemic of Dengue-1 in a Remote Village in Rural Laos. PLoS Neglected Tropical Diseases, 7(8), [e2360]. https://doi.org/10.1371/journal.pntd.0002360

An Epidemic of Dengue-1 in a Remote Village in Rural Laos. / Dubot-Pérès, Audrey; Vongphrachanh, Phengta; Denny, Justin; Phetsouvanh, Rattanaphone; Linthavong, Singharath; Sengkeopraseuth, Bounthanom; Khasing, Amphai; Xaythideth, Vimattha; Moore, Catrin E.; Vongsouvath, Manivanh; Castonguay-Vanier, Josée; Sibounheuang, Bountoy; Taojaikong, Thaksinaporn; Chanthongthip, Anisone; de Lamballerie, Xavier; Newton, Paul N.

In: PLoS Neglected Tropical Diseases, Vol. 7, No. 8, e2360, 08.2013.

Research output: Contribution to journalArticle

Dubot-Pérès, A, Vongphrachanh, P, Denny, J, Phetsouvanh, R, Linthavong, S, Sengkeopraseuth, B, Khasing, A, Xaythideth, V, Moore, CE, Vongsouvath, M, Castonguay-Vanier, J, Sibounheuang, B, Taojaikong, T, Chanthongthip, A, de Lamballerie, X & Newton, PN 2013, 'An Epidemic of Dengue-1 in a Remote Village in Rural Laos', PLoS Neglected Tropical Diseases, vol. 7, no. 8, e2360. https://doi.org/10.1371/journal.pntd.0002360
Dubot-Pérès A, Vongphrachanh P, Denny J, Phetsouvanh R, Linthavong S, Sengkeopraseuth B et al. An Epidemic of Dengue-1 in a Remote Village in Rural Laos. PLoS Neglected Tropical Diseases. 2013 Aug;7(8). e2360. https://doi.org/10.1371/journal.pntd.0002360
Dubot-Pérès, Audrey ; Vongphrachanh, Phengta ; Denny, Justin ; Phetsouvanh, Rattanaphone ; Linthavong, Singharath ; Sengkeopraseuth, Bounthanom ; Khasing, Amphai ; Xaythideth, Vimattha ; Moore, Catrin E. ; Vongsouvath, Manivanh ; Castonguay-Vanier, Josée ; Sibounheuang, Bountoy ; Taojaikong, Thaksinaporn ; Chanthongthip, Anisone ; de Lamballerie, Xavier ; Newton, Paul N. / An Epidemic of Dengue-1 in a Remote Village in Rural Laos. In: PLoS Neglected Tropical Diseases. 2013 ; Vol. 7, No. 8.
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