Abstract
Gene knockout studies in mice, and a recent case report, have demonstrated that insulin-like growth factors (IGFs) are major mediators of pre- and postnatal growth, whereas the growth-promoting role of growth hormone (GH) appears to be confined largely to the postnatal period. The IGF axis is now known to consist of the growth factors themselves and at least seven, and probably ten, IGF-binding proteins. These act either by regulating the availability of IGFs to their receptors, or directly on their target cells. Because of the difficulties associated with GH provocative testing, the central role of IGFs in pre- and postnatal growth, and the ease of assaying the various components of the IGF axis, it is suggested that the differential diagnosis of short stature should be based on the concept of IGF deficiency rather than on GH secretory status.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 17-19 |
| Number of pages | 3 |
| Journal | Acta Paediatrica, International Journal of Paediatrics, Supplement |
| Volume | 86 |
| Issue number | 423 |
| State | Published - 1997 |
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Keywords
- Diagnosis
- Growth hormone
- Insulin-like growth factor
- Insulin-like growth factor receptor
- Insulin-like growth factor- binding proteins
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
An endocrinologist's approach to the growth hormone-insulin-like growth factor axis. / Rosenfeld, Ronald (Ron).
In: Acta Paediatrica, International Journal of Paediatrics, Supplement, Vol. 86, No. 423, 1997, p. 17-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An endocrinologist's approach to the growth hormone-insulin-like growth factor axis
AU - Rosenfeld, Ronald (Ron)
PY - 1997
Y1 - 1997
N2 - Gene knockout studies in mice, and a recent case report, have demonstrated that insulin-like growth factors (IGFs) are major mediators of pre- and postnatal growth, whereas the growth-promoting role of growth hormone (GH) appears to be confined largely to the postnatal period. The IGF axis is now known to consist of the growth factors themselves and at least seven, and probably ten, IGF-binding proteins. These act either by regulating the availability of IGFs to their receptors, or directly on their target cells. Because of the difficulties associated with GH provocative testing, the central role of IGFs in pre- and postnatal growth, and the ease of assaying the various components of the IGF axis, it is suggested that the differential diagnosis of short stature should be based on the concept of IGF deficiency rather than on GH secretory status.
AB - Gene knockout studies in mice, and a recent case report, have demonstrated that insulin-like growth factors (IGFs) are major mediators of pre- and postnatal growth, whereas the growth-promoting role of growth hormone (GH) appears to be confined largely to the postnatal period. The IGF axis is now known to consist of the growth factors themselves and at least seven, and probably ten, IGF-binding proteins. These act either by regulating the availability of IGFs to their receptors, or directly on their target cells. Because of the difficulties associated with GH provocative testing, the central role of IGFs in pre- and postnatal growth, and the ease of assaying the various components of the IGF axis, it is suggested that the differential diagnosis of short stature should be based on the concept of IGF deficiency rather than on GH secretory status.
KW - Diagnosis
KW - Growth hormone
KW - Insulin-like growth factor
KW - Insulin-like growth factor receptor
KW - Insulin-like growth factor- binding proteins
UR - http://www.scopus.com/inward/record.url?scp=0030784920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030784920&partnerID=8YFLogxK
M3 - Article
C2 - 9401533
AN - SCOPUS:0030784920
VL - 86
SP - 17
EP - 19
JO - Acta Paediatrica, International Journal of Paediatrics, Supplement
JF - Acta Paediatrica, International Journal of Paediatrics, Supplement
SN - 0803-5326
IS - 423
ER -