Abstract
The substitution of the sterically hindered carbon of the potent thyroid hormone agonist, GC-1, was effected by a reaction based on the solvolysis of the benzylic hydroxyl group. The reaction was found to proceed in high yield with a variety of nucleophiles including alcohols, thiols, allyl silanes and electron-rich aromatic compounds, providing a convenient route to the synthesis of new thyroid hormone analogues. Copyright (C) 1998 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 1179-1183 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 6 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1998 |
Externally published | Yes |
Keywords
- S(N)1
- Thyroid hormone
- Thyromimetic
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry