An autologous tissue implant, neocart, for treatment of hyaline cartilage injury in the knee

Hannah R. Jones, Dennis Crawford

Research output: Contribution to journalArticle

Abstract

NeoCart is an autologous cartilage tissue-engineered implant designed for use in repair of articular cartilage injuries. It uniquely combines a type I bovine-derived collagen scaffold with autogenous chondrocytes and bioreactor treatment. It is currently in the third phase of an investigational study in the United States for treatment of symptomatic articular cartilage lesions of the distal femur. This multicenter, prospective, randomized controlled trial directly compares changes of multiple patient-reported outcome measures over 3 years with a control group undergoing microfracture surgery. This article describes the study design and indications for enrollment in the phase III trial. The technical elements of NeoCart culture and production process, surgical implantation procedure, and rehabilitation guidelines are outlined. In addition, we review previously published findings from the completed phase I safety and phase II exploratory trials.

Original languageEnglish (US)
Pages (from-to)264-270
Number of pages7
JournalOperative Techniques in Orthopaedics
Volume24
Issue number4
DOIs
StatePublished - Dec 1 2014

Fingerprint

Hyaline Cartilage
Knee Injuries
Articular Cartilage
Stress Fractures
Bioreactors
Chondrocytes
Femur
Cartilage
Collagen
Rehabilitation
Randomized Controlled Trials
Guidelines
Safety
Control Groups
Wounds and Injuries
Therapeutics
Patient Reported Outcome Measures

Keywords

  • Articular cartilage injury
  • Autologous cartilage repair
  • Chondral repair
  • Chondrocyte

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

An autologous tissue implant, neocart, for treatment of hyaline cartilage injury in the knee. / Jones, Hannah R.; Crawford, Dennis.

In: Operative Techniques in Orthopaedics, Vol. 24, No. 4, 01.12.2014, p. 264-270.

Research output: Contribution to journalArticle

@article{8b231e27fa754c2da82d82fe9f9c86d7,
title = "An autologous tissue implant, neocart, for treatment of hyaline cartilage injury in the knee",
abstract = "NeoCart is an autologous cartilage tissue-engineered implant designed for use in repair of articular cartilage injuries. It uniquely combines a type I bovine-derived collagen scaffold with autogenous chondrocytes and bioreactor treatment. It is currently in the third phase of an investigational study in the United States for treatment of symptomatic articular cartilage lesions of the distal femur. This multicenter, prospective, randomized controlled trial directly compares changes of multiple patient-reported outcome measures over 3 years with a control group undergoing microfracture surgery. This article describes the study design and indications for enrollment in the phase III trial. The technical elements of NeoCart culture and production process, surgical implantation procedure, and rehabilitation guidelines are outlined. In addition, we review previously published findings from the completed phase I safety and phase II exploratory trials.",
keywords = "Articular cartilage injury, Autologous cartilage repair, Chondral repair, Chondrocyte",
author = "Jones, {Hannah R.} and Dennis Crawford",
year = "2014",
month = "12",
day = "1",
doi = "10.1053/j.oto.2014.07.002",
language = "English (US)",
volume = "24",
pages = "264--270",
journal = "Operative Techniques in Orthopaedics",
issn = "1048-6666",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - An autologous tissue implant, neocart, for treatment of hyaline cartilage injury in the knee

AU - Jones, Hannah R.

AU - Crawford, Dennis

PY - 2014/12/1

Y1 - 2014/12/1

N2 - NeoCart is an autologous cartilage tissue-engineered implant designed for use in repair of articular cartilage injuries. It uniquely combines a type I bovine-derived collagen scaffold with autogenous chondrocytes and bioreactor treatment. It is currently in the third phase of an investigational study in the United States for treatment of symptomatic articular cartilage lesions of the distal femur. This multicenter, prospective, randomized controlled trial directly compares changes of multiple patient-reported outcome measures over 3 years with a control group undergoing microfracture surgery. This article describes the study design and indications for enrollment in the phase III trial. The technical elements of NeoCart culture and production process, surgical implantation procedure, and rehabilitation guidelines are outlined. In addition, we review previously published findings from the completed phase I safety and phase II exploratory trials.

AB - NeoCart is an autologous cartilage tissue-engineered implant designed for use in repair of articular cartilage injuries. It uniquely combines a type I bovine-derived collagen scaffold with autogenous chondrocytes and bioreactor treatment. It is currently in the third phase of an investigational study in the United States for treatment of symptomatic articular cartilage lesions of the distal femur. This multicenter, prospective, randomized controlled trial directly compares changes of multiple patient-reported outcome measures over 3 years with a control group undergoing microfracture surgery. This article describes the study design and indications for enrollment in the phase III trial. The technical elements of NeoCart culture and production process, surgical implantation procedure, and rehabilitation guidelines are outlined. In addition, we review previously published findings from the completed phase I safety and phase II exploratory trials.

KW - Articular cartilage injury

KW - Autologous cartilage repair

KW - Chondral repair

KW - Chondrocyte

UR - http://www.scopus.com/inward/record.url?scp=84919498044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919498044&partnerID=8YFLogxK

U2 - 10.1053/j.oto.2014.07.002

DO - 10.1053/j.oto.2014.07.002

M3 - Article

AN - SCOPUS:84919498044

VL - 24

SP - 264

EP - 270

JO - Operative Techniques in Orthopaedics

JF - Operative Techniques in Orthopaedics

SN - 1048-6666

IS - 4

ER -