An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo

John Webber, Yu Luo, Richard Crilly, David Fromm, David Kessel

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

CDF1 mice bearing the colon-26 tumor were treated with aminolevulinic acid (200 mg kg-1) by tail-vein injection, with tumor sites irradiated 4 h later at 633 nm (75-120 J cm-2). 10 h after irradiation, samples of tumors were removed for histology studies and analysis of DNA fragmentation by static gel electrophoresis. The resulting patterns indicate an apoptotic response to photodynamic therapy with endogenously formed protoporphyrin.

Original languageEnglish (US)
Pages (from-to)209-211
Number of pages3
JournalJournal of Photochemistry and Photobiology B: Biology
Volume35
Issue number3
DOIs
StatePublished - Sep 1996
Externally publishedYes

Fingerprint

protoporphyrin
Photodynamic therapy
Photochemotherapy
Tumors
therapy
tumors
therapeutics
neoplasms
Bearings (structural)
Neoplasms
Aminolevulinic Acid
aminolevulinic acid
Histology
histology
DNA fragmentation
DNA Fragmentation
electrophoresis
Electrophoresis
veins
gel electrophoresis

Keywords

  • ALA
  • Apoptosis
  • Photodynamic therapy
  • Protoporphyrin

ASJC Scopus subject areas

  • Plant Science
  • Bioengineering
  • Physical and Theoretical Chemistry

Cite this

An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo. / Webber, John; Luo, Yu; Crilly, Richard; Fromm, David; Kessel, David.

In: Journal of Photochemistry and Photobiology B: Biology, Vol. 35, No. 3, 09.1996, p. 209-211.

Research output: Contribution to journalArticle

@article{280f76bc71f74127ab36c0a18ab47512,
title = "An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo",
abstract = "CDF1 mice bearing the colon-26 tumor were treated with aminolevulinic acid (200 mg kg-1) by tail-vein injection, with tumor sites irradiated 4 h later at 633 nm (75-120 J cm-2). 10 h after irradiation, samples of tumors were removed for histology studies and analysis of DNA fragmentation by static gel electrophoresis. The resulting patterns indicate an apoptotic response to photodynamic therapy with endogenously formed protoporphyrin.",
keywords = "ALA, Apoptosis, Photodynamic therapy, Protoporphyrin",
author = "John Webber and Yu Luo and Richard Crilly and David Fromm and David Kessel",
year = "1996",
month = "9",
doi = "10.1016/S1011-1344(96)07291-0",
language = "English (US)",
volume = "35",
pages = "209--211",
journal = "Journal of photochemistry and photobiology. B, Biology",
issn = "1011-1344",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo

AU - Webber, John

AU - Luo, Yu

AU - Crilly, Richard

AU - Fromm, David

AU - Kessel, David

PY - 1996/9

Y1 - 1996/9

N2 - CDF1 mice bearing the colon-26 tumor were treated with aminolevulinic acid (200 mg kg-1) by tail-vein injection, with tumor sites irradiated 4 h later at 633 nm (75-120 J cm-2). 10 h after irradiation, samples of tumors were removed for histology studies and analysis of DNA fragmentation by static gel electrophoresis. The resulting patterns indicate an apoptotic response to photodynamic therapy with endogenously formed protoporphyrin.

AB - CDF1 mice bearing the colon-26 tumor were treated with aminolevulinic acid (200 mg kg-1) by tail-vein injection, with tumor sites irradiated 4 h later at 633 nm (75-120 J cm-2). 10 h after irradiation, samples of tumors were removed for histology studies and analysis of DNA fragmentation by static gel electrophoresis. The resulting patterns indicate an apoptotic response to photodynamic therapy with endogenously formed protoporphyrin.

KW - ALA

KW - Apoptosis

KW - Photodynamic therapy

KW - Protoporphyrin

UR - http://www.scopus.com/inward/record.url?scp=0030248768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030248768&partnerID=8YFLogxK

U2 - 10.1016/S1011-1344(96)07291-0

DO - 10.1016/S1011-1344(96)07291-0

M3 - Article

VL - 35

SP - 209

EP - 211

JO - Journal of photochemistry and photobiology. B, Biology

JF - Journal of photochemistry and photobiology. B, Biology

SN - 1011-1344

IS - 3

ER -