An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo

John Webber, Yu Luo, Richard Crilly, David Fromm, David Kessel

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

CDF1 mice bearing the colon-26 tumor were treated with aminolevulinic acid (200 mg kg-1) by tail-vein injection, with tumor sites irradiated 4 h later at 633 nm (75-120 J cm-2). 10 h after irradiation, samples of tumors were removed for histology studies and analysis of DNA fragmentation by static gel electrophoresis. The resulting patterns indicate an apoptotic response to photodynamic therapy with endogenously formed protoporphyrin.

Original languageEnglish (US)
Pages (from-to)209-211
Number of pages3
JournalJournal of Photochemistry and Photobiology B: Biology
Volume35
Issue number3
DOIs
StatePublished - Sep 1 1996

Keywords

  • ALA
  • Apoptosis
  • Photodynamic therapy
  • Protoporphyrin

ASJC Scopus subject areas

  • Radiation
  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

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