An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo

John Webber; Yu Luo; Richard Crilly; David Fromm; David Kessel

doi:10.1016/S1011-1344(96)07291-0

An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo

John Webber, Yu Luo, Richard Crilly, David Fromm, David Kessel

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

CDF₁ mice bearing the colon-26 tumor were treated with aminolevulinic acid (200 mg kg^-1) by tail-vein injection, with tumor sites irradiated 4 h later at 633 nm (75-120 J cm^-2). 10 h after irradiation, samples of tumors were removed for histology studies and analysis of DNA fragmentation by static gel electrophoresis. The resulting patterns indicate an apoptotic response to photodynamic therapy with endogenously formed protoporphyrin.

Original language	English (US)
Pages (from-to)	209-211
Number of pages	3
Journal	Journal of Photochemistry and Photobiology B: Biology
Volume	35
Issue number	3
DOIs	https://doi.org/10.1016/S1011-1344(96)07291-0
State	Published - Sep 1996
Externally published	Yes

Keywords

ALA
Apoptosis
Photodynamic therapy
Protoporphyrin

ASJC Scopus subject areas

Radiation
Radiological and Ultrasound Technology
Biophysics
Radiology Nuclear Medicine and imaging

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10.1016/S1011-1344(96)07291-0

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title = "An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo",

abstract = "CDF1 mice bearing the colon-26 tumor were treated with aminolevulinic acid (200 mg kg-1) by tail-vein injection, with tumor sites irradiated 4 h later at 633 nm (75-120 J cm-2). 10 h after irradiation, samples of tumors were removed for histology studies and analysis of DNA fragmentation by static gel electrophoresis. The resulting patterns indicate an apoptotic response to photodynamic therapy with endogenously formed protoporphyrin.",

keywords = "ALA, Apoptosis, Photodynamic therapy, Protoporphyrin",

author = "John Webber and Yu Luo and Richard Crilly and David Fromm and David Kessel",

year = "1996",

month = sep,

doi = "10.1016/S1011-1344(96)07291-0",

language = "English (US)",

volume = "35",

pages = "209--211",

journal = "Journal of Photochemistry and Photobiology B: Biology",

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T1 - An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo

AU - Webber, John

AU - Luo, Yu

AU - Crilly, Richard

AU - Fromm, David

AU - Kessel, David

PY - 1996/9

Y1 - 1996/9

N2 - CDF1 mice bearing the colon-26 tumor were treated with aminolevulinic acid (200 mg kg-1) by tail-vein injection, with tumor sites irradiated 4 h later at 633 nm (75-120 J cm-2). 10 h after irradiation, samples of tumors were removed for histology studies and analysis of DNA fragmentation by static gel electrophoresis. The resulting patterns indicate an apoptotic response to photodynamic therapy with endogenously formed protoporphyrin.

AB - CDF1 mice bearing the colon-26 tumor were treated with aminolevulinic acid (200 mg kg-1) by tail-vein injection, with tumor sites irradiated 4 h later at 633 nm (75-120 J cm-2). 10 h after irradiation, samples of tumors were removed for histology studies and analysis of DNA fragmentation by static gel electrophoresis. The resulting patterns indicate an apoptotic response to photodynamic therapy with endogenously formed protoporphyrin.

KW - ALA

KW - Apoptosis

KW - Photodynamic therapy

KW - Protoporphyrin

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AN - SCOPUS:0030248768

SN - 1011-1344

VL - 35

SP - 209

EP - 211

JO - Journal of Photochemistry and Photobiology B: Biology

JF - Journal of Photochemistry and Photobiology B: Biology

IS - 3

ER -

An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo

Abstract

Keywords

ASJC Scopus subject areas

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