An androgen binding protein in the cyst fluid of patients with polycystic ovary syndrome

R. A. Vigersky, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Androgen binding proteins (ABP) have not been described in the ovary. The authors have studied cyst fluids from three patients with the Polycystic Ovary Syndrome and one patient with choriocarcinoma for the presence of ABP. All contained a high affinity, low capacity binding protein for dihydrotestosterone and 17β estradiol. Comparison of this protein with the plasma androgen binding protein (TeBG) in polyacrylamide gel electrophoresis and equilibrium dialysis did not reveal any significant differences in molecular size (K(R)), net charge (Y(O)), radius R, molecular weight (mol wt), heat stability, steroid specificity, or binding affinity (K(a)). Cyst fluid and plasma could not be distinguished from each other on the basis of protein composition as measured by cellulose acetate electrophoresis. In the one patient studied, the binding capacity for DHT in cyst fluid and plasma was 58.1 and 16.1 ng/Gm protein, respectively.

Original languageEnglish (US)
Pages (from-to)817-823
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume43
Issue number4
StatePublished - 1976
Externally publishedYes

Fingerprint

Androgen-Binding Protein
Cyst Fluid
Polycystic Ovary Syndrome
Electrophoresis
Plasmas
Fluids
Cellulose Acetate Electrophoresis
Choriocarcinoma
Proteins
Dialysis
Dihydrotestosterone
Blood Proteins
Polyacrylamide Gel Electrophoresis
Ovary
Estradiol
Carrier Proteins
Hot Temperature
Molecular Weight
Molecular weight
Steroids

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

An androgen binding protein in the cyst fluid of patients with polycystic ovary syndrome. / Vigersky, R. A.; Loriaux, Donald (Lynn).

In: Journal of Clinical Endocrinology and Metabolism, Vol. 43, No. 4, 1976, p. 817-823.

Research output: Contribution to journalArticle

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