TY - JOUR
T1 - An ancient developmental induction
T2 - Heat-shock proteins induced in sporulation and oogenesis
AU - Kurtz, Stephen
AU - Rossi, Janice
AU - Petko, Lawrence
AU - Lindquist, Susan
PY - 1986
Y1 - 1986
N2 - Every eukaryotic and prokaryotic organism tested to date synthesizes a small number of heat-shock proteins in response to heat and other forms of stress. A particular pattern of heat-shock gene expression was observed during ascospore development in Saccharomyces: heat-shock proteins hsp26 and hsp84 were strongly induced, whereas hsp70, the most highly conserved of these proteins, was neither induced nor inducible by heat shock. Instead, two proteins related to hsp70 were induced. A strikingly similar pattern of expression occurs during oogenesis in Drosophila, suggesting that it may be one of the earliest developmental pathways to evolve in eukaryotic cells.
AB - Every eukaryotic and prokaryotic organism tested to date synthesizes a small number of heat-shock proteins in response to heat and other forms of stress. A particular pattern of heat-shock gene expression was observed during ascospore development in Saccharomyces: heat-shock proteins hsp26 and hsp84 were strongly induced, whereas hsp70, the most highly conserved of these proteins, was neither induced nor inducible by heat shock. Instead, two proteins related to hsp70 were induced. A strikingly similar pattern of expression occurs during oogenesis in Drosophila, suggesting that it may be one of the earliest developmental pathways to evolve in eukaryotic cells.
UR - http://www.scopus.com/inward/record.url?scp=0022462428&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022462428&partnerID=8YFLogxK
U2 - 10.1126/science.3511530
DO - 10.1126/science.3511530
M3 - Article
C2 - 3511530
AN - SCOPUS:0022462428
SN - 0036-8075
VL - 231
SP - 1154
EP - 1157
JO - Science
JF - Science
IS - 4742
ER -