An analysis of the effects of apomorphine and haloperidol on the release of [3H]-dopamine and [3H]-noradrenaline from rabbit brain slices

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Abstract

The effects of apomorphine and haloperidol on the K+-induced release of [3H]-dopamine from striatal slices and [3H]-noradrenaline from cerebellar slices were examined. Apomorphine (0.01-1 μM) reduced the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline from cerebellar slices unaffected. A higher concentration (10 μM) of apomorphine increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Haloperidol (0.01-1 nM) increased the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline unaffected. Haloperidol in higher concentrations (10-100 nM) increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Both compounds inhibited the uptake of [3H]-dopamine into striatal slices and [3H] noradrenaline into cerebellar slices. In low concentrations both compounds showed selectivity for dopaminergic receptor sites, apomorphine stimulating and haloperidol inhibiting pre-synaptic dopamine receptors. Higher concentrations of these compounds showed a non-selective action.

Original languageEnglish (US)
Pages (from-to)18-29
Number of pages12
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume250
Issue number1
StatePublished - 1981
Externally publishedYes

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Apomorphine
Haloperidol
Corpus Striatum
Dopamine
Norepinephrine
Rabbits
Brain
Neurotransmitter Receptor
Dopamine Receptors

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "An analysis of the effects of apomorphine and haloperidol on the release of [3H]-dopamine and [3H]-noradrenaline from rabbit brain slices",
abstract = "The effects of apomorphine and haloperidol on the K+-induced release of [3H]-dopamine from striatal slices and [3H]-noradrenaline from cerebellar slices were examined. Apomorphine (0.01-1 μM) reduced the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline from cerebellar slices unaffected. A higher concentration (10 μM) of apomorphine increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Haloperidol (0.01-1 nM) increased the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline unaffected. Haloperidol in higher concentrations (10-100 nM) increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Both compounds inhibited the uptake of [3H]-dopamine into striatal slices and [3H] noradrenaline into cerebellar slices. In low concentrations both compounds showed selectivity for dopaminergic receptor sites, apomorphine stimulating and haloperidol inhibiting pre-synaptic dopamine receptors. Higher concentrations of these compounds showed a non-selective action.",
author = "Martin Kelly",
year = "1981",
language = "English (US)",
volume = "250",
pages = "18--29",
journal = "Archives Internationales de Pharmacodynamie et de Therapie",
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number = "1",

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T1 - An analysis of the effects of apomorphine and haloperidol on the release of [3H]-dopamine and [3H]-noradrenaline from rabbit brain slices

AU - Kelly, Martin

PY - 1981

Y1 - 1981

N2 - The effects of apomorphine and haloperidol on the K+-induced release of [3H]-dopamine from striatal slices and [3H]-noradrenaline from cerebellar slices were examined. Apomorphine (0.01-1 μM) reduced the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline from cerebellar slices unaffected. A higher concentration (10 μM) of apomorphine increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Haloperidol (0.01-1 nM) increased the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline unaffected. Haloperidol in higher concentrations (10-100 nM) increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Both compounds inhibited the uptake of [3H]-dopamine into striatal slices and [3H] noradrenaline into cerebellar slices. In low concentrations both compounds showed selectivity for dopaminergic receptor sites, apomorphine stimulating and haloperidol inhibiting pre-synaptic dopamine receptors. Higher concentrations of these compounds showed a non-selective action.

AB - The effects of apomorphine and haloperidol on the K+-induced release of [3H]-dopamine from striatal slices and [3H]-noradrenaline from cerebellar slices were examined. Apomorphine (0.01-1 μM) reduced the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline from cerebellar slices unaffected. A higher concentration (10 μM) of apomorphine increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Haloperidol (0.01-1 nM) increased the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline unaffected. Haloperidol in higher concentrations (10-100 nM) increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Both compounds inhibited the uptake of [3H]-dopamine into striatal slices and [3H] noradrenaline into cerebellar slices. In low concentrations both compounds showed selectivity for dopaminergic receptor sites, apomorphine stimulating and haloperidol inhibiting pre-synaptic dopamine receptors. Higher concentrations of these compounds showed a non-selective action.

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