An analysis of the effects of apomorphine and haloperidol on the release of [3H]-dopamine and [3H]-noradrenaline from rabbit brain slices

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effects of apomorphine and haloperidol on the K+-induced release of [3H]-dopamine from striatal slices and [3H]-noradrenaline from cerebellar slices were examined. Apomorphine (0.01-1 μM) reduced the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline from cerebellar slices unaffected. A higher concentration (10 μM) of apomorphine increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Haloperidol (0.01-1 nM) increased the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline unaffected. Haloperidol in higher concentrations (10-100 nM) increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Both compounds inhibited the uptake of [3H]-dopamine into striatal slices and [3H] noradrenaline into cerebellar slices. In low concentrations both compounds showed selectivity for dopaminergic receptor sites, apomorphine stimulating and haloperidol inhibiting pre-synaptic dopamine receptors. Higher concentrations of these compounds showed a non-selective action.

Original languageEnglish (US)
Pages (from-to)18-29
Number of pages12
JournalArchives internationales de pharmacodynamie et de therapie
Volume250
Issue number1
StatePublished - Jan 1 1981

    Fingerprint

ASJC Scopus subject areas

  • Pharmacology

Cite this