An analysis of 100 primary cadaver kidney transplants

J. M. Barry, D. H. Craig, S. M. Fischer, E. F. Fuchs, R. K. Lawson, W. M. Bennett

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A multifactorial analysis of 100 consecutive first cadaver kidney transplants was done to document the current status of this treatment for end stage renal disease and to determine the influence of the following variables on kidney losses owing to rejection: splenectomy, pre-transplant transfusions, transfusion at the transplantation, recipient sex, pre-transplant nephrectomy, donor and recipient A, B or O blood group, human leukocyte A and B antigen mismatches, kidney preservation method, donor treatment with methylprednisolone and cyclophosphamide, recipient treatment with antilymphocyte serum or antilymphoblast globulin and a low dose of steroid treatment for rejection. Pretransplant splenectomy for leukopenia, 5 or more pre-transplant blood transfusions and pre-transplant transfusions without development of circulating cytotoxic antibodies significantly reduced kidney losses owing to rejection (p less than 0.05). A low dose of steroid treatment for rejection resulted in a trend towards improved patient survival without sacrificing kidney graft survival. Clinical studies demonstrating decreases in kidney graft rejection should be controlled for pretransplant blood transfusions and, possibly, for pre-transplant splenectomy for hypersplenism.

Original languageEnglish (US)
Pages (from-to)783-786
Number of pages4
JournalUnknown Journal
Volume124
Issue number6
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'An analysis of 100 primary cadaver kidney transplants'. Together they form a unique fingerprint.

  • Cite this

    Barry, J. M., Craig, D. H., Fischer, S. M., Fuchs, E. F., Lawson, R. K., & Bennett, W. M. (1980). An analysis of 100 primary cadaver kidney transplants. Unknown Journal, 124(6), 783-786. https://doi.org/10.1016/S0022-5347(17)55662-1