An analogy between the evolution of drug resistance in bacterial communities and malignant tissues

Guillaume Lambert; Luis Estévez-Salmeron; Steve Oh; David Liao; Beverly M. Emerson; Thea D. Tlsty; Robert H. Austin

doi:10.1038/nrc3039

An analogy between the evolution of drug resistance in bacterial communities and malignant tissues

Guillaume Lambert, Luis Estévez-Salmeron, Steve Oh, David Liao, Beverly M. Emerson, Thea D. Tlsty, Robert H. Austin

Research output: Contribution to journal › Review article › peer-review

126 Scopus citations

Abstract

Cancer cells rapidly evolve drug resistance through somatic evolution and, in order to continue growth in the metastatic phase, violate the organism-wide consensus of regulated growth and beneficial communal interactions. We suggest that there is a fundamental mechanistic connection between the rapid evolution of resistance to chemotherapy in cellular communities within malignant tissues and the rapid evolution of antibiotic resistance in bacterial communities. We propose that this evolution is the result of a programmed and collective stress response performed by interacting cells, and that, given this fundamental connection, studying bacterial communities can provide deeper insights into the dynamics of adaptation and the evolution of cells within tumours.

Original language	English (US)
Pages (from-to)	375-382
Number of pages	8
Journal	Nature Reviews Cancer
Volume	11
Issue number	5
DOIs	https://doi.org/10.1038/nrc3039
State	Published - May 2011
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "An analogy between the evolution of drug resistance in bacterial communities and malignant tissues",

abstract = "Cancer cells rapidly evolve drug resistance through somatic evolution and, in order to continue growth in the metastatic phase, violate the organism-wide consensus of regulated growth and beneficial communal interactions. We suggest that there is a fundamental mechanistic connection between the rapid evolution of resistance to chemotherapy in cellular communities within malignant tissues and the rapid evolution of antibiotic resistance in bacterial communities. We propose that this evolution is the result of a programmed and collective stress response performed by interacting cells, and that, given this fundamental connection, studying bacterial communities can provide deeper insights into the dynamics of adaptation and the evolution of cells within tumours.",

author = "Guillaume Lambert and Luis Est{\'e}vez-Salmeron and Steve Oh and David Liao and Emerson, {Beverly M.} and Tlsty, {Thea D.} and Austin, {Robert H.}",

note = "Funding Information: We wish to thank D. Coffey and A. Barker for their helpful comments. The research described was supported by award U54CA143803 from the US National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the US National Cancer Institute or the US National Institutes of Health.",

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AU - Estévez-Salmeron, Luis

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AU - Liao, David

AU - Emerson, Beverly M.

AU - Tlsty, Thea D.

AU - Austin, Robert H.

N1 - Funding Information: We wish to thank D. Coffey and A. Barker for their helpful comments. The research described was supported by award U54CA143803 from the US National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the US National Cancer Institute or the US National Institutes of Health.

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N2 - Cancer cells rapidly evolve drug resistance through somatic evolution and, in order to continue growth in the metastatic phase, violate the organism-wide consensus of regulated growth and beneficial communal interactions. We suggest that there is a fundamental mechanistic connection between the rapid evolution of resistance to chemotherapy in cellular communities within malignant tissues and the rapid evolution of antibiotic resistance in bacterial communities. We propose that this evolution is the result of a programmed and collective stress response performed by interacting cells, and that, given this fundamental connection, studying bacterial communities can provide deeper insights into the dynamics of adaptation and the evolution of cells within tumours.

AB - Cancer cells rapidly evolve drug resistance through somatic evolution and, in order to continue growth in the metastatic phase, violate the organism-wide consensus of regulated growth and beneficial communal interactions. We suggest that there is a fundamental mechanistic connection between the rapid evolution of resistance to chemotherapy in cellular communities within malignant tissues and the rapid evolution of antibiotic resistance in bacterial communities. We propose that this evolution is the result of a programmed and collective stress response performed by interacting cells, and that, given this fundamental connection, studying bacterial communities can provide deeper insights into the dynamics of adaptation and the evolution of cells within tumours.

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An analogy between the evolution of drug resistance in bacterial communities and malignant tissues

Abstract

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