An analogy between the evolution of drug resistance in bacterial communities and malignant tissues

Guillaume Lambert, Luis Estévez-Salmeron, Steve Oh, David Liao, Beverly Emerson, Thea D. Tlsty, Robert H. Austin

Research output: Contribution to journalReview article

100 Citations (Scopus)

Abstract

Cancer cells rapidly evolve drug resistance through somatic evolution and, in order to continue growth in the metastatic phase, violate the organism-wide consensus of regulated growth and beneficial communal interactions. We suggest that there is a fundamental mechanistic connection between the rapid evolution of resistance to chemotherapy in cellular communities within malignant tissues and the rapid evolution of antibiotic resistance in bacterial communities. We propose that this evolution is the result of a programmed and collective stress response performed by interacting cells, and that, given this fundamental connection, studying bacterial communities can provide deeper insights into the dynamics of adaptation and the evolution of cells within tumours.

Original languageEnglish (US)
Pages (from-to)375-382
Number of pages8
JournalNature Reviews Cancer
Volume11
Issue number5
DOIs
StatePublished - May 1 2011
Externally publishedYes

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Bacterial Drug Resistance
Clonal Evolution
Growth
Drug Resistance
Neoplasms
Drug Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lambert, G., Estévez-Salmeron, L., Oh, S., Liao, D., Emerson, B., Tlsty, T. D., & Austin, R. H. (2011). An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nature Reviews Cancer, 11(5), 375-382. https://doi.org/10.1038/nrc3039

An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. / Lambert, Guillaume; Estévez-Salmeron, Luis; Oh, Steve; Liao, David; Emerson, Beverly; Tlsty, Thea D.; Austin, Robert H.

In: Nature Reviews Cancer, Vol. 11, No. 5, 01.05.2011, p. 375-382.

Research output: Contribution to journalReview article

Lambert, G, Estévez-Salmeron, L, Oh, S, Liao, D, Emerson, B, Tlsty, TD & Austin, RH 2011, 'An analogy between the evolution of drug resistance in bacterial communities and malignant tissues', Nature Reviews Cancer, vol. 11, no. 5, pp. 375-382. https://doi.org/10.1038/nrc3039
Lambert, Guillaume ; Estévez-Salmeron, Luis ; Oh, Steve ; Liao, David ; Emerson, Beverly ; Tlsty, Thea D. ; Austin, Robert H. / An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. In: Nature Reviews Cancer. 2011 ; Vol. 11, No. 5. pp. 375-382.
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