Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer's disease Neurons

Ravi Rajmohan, P (Hemachandra) Reddy

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Amyloid-beta (Aβ) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease (AD). However, the loss of synapses and dysfunctions of neurotransmission are more directly tied to disease severity. The role of these lesions in the pathoetiological progression of the disease remains contested. Biochemical, cellular, molecular, and pathological studies provided several lines of evidence and improved our understanding of how Aβ and hyperphosphorylated tau accumulation may directly harm synapses and alter neurotransmission. In vitro evidence suggests that Aβ and hyperphosphorylated tau have both direct and indirect cytotoxic effects that affect neurotransmission, axonal transport, signaling cascades, organelle function, and immune response in ways that lead to synaptic loss and dysfunctions in neurotransmitter release. Observations in preclinical models and autopsy studies support these findings, suggesting that while the pathoetiology of positive lesions remains elusive, their removal may reduce disease severity and progression. The purpose of this article is to highlight the need for further investigation of the role of tau in disease progression and its interactions with Aβ and neurotransmitters alike.

Original languageEnglish (US)
Pages (from-to)975-999
Number of pages25
JournalJournal of Alzheimer's Disease
Volume57
Issue number4
DOIs
StatePublished - 2017
Externally publishedYes

Fingerprint

Amyloid
Synaptic Transmission
Synapses
Disease Progression
Alzheimer Disease
Neurons
Neurotransmitter Agents
Axonal Transport
Organelles
Autopsy

Keywords

  • Amyloid
  • neurotransmitters
  • synapse
  • tau

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer's disease Neurons. / Rajmohan, Ravi; Reddy, P (Hemachandra).

In: Journal of Alzheimer's Disease, Vol. 57, No. 4, 2017, p. 975-999.

Research output: Contribution to journalReview article

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