Amperometric glucose sensors: Sources of error and potential benefit of redundancy

Jessica R. Castle, W. Kenneth Ward

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


Amperometric glucose sensors have advanced the care of patients with diabetes and are being studied to control insulin delivery in the research setting. However, at times, currently available sensors demonstrate suboptimal accuracy, which can result from calibration error, sensor drift, or lag. Inaccuracy can be particularly problematic in a closed-loop glycemic control system. In such a system, the use of two sensors allows selection of the more accurate sensor as the input to the controller. In our studies in subjects with type 1 diabetes, the accuracy of the better of two sensors significantly exceeded the accuracy of a single, randomly selected sensor. If an array with three or more sensors were available, it would likely allow even better accuracy with the use of voting.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalJournal of Diabetes Science and Technology
Issue number1
StatePublished - Jan 2010


  • Accuracy
  • Closed-loop system
  • Multiple
  • Redundancy
  • Sensor

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Bioengineering
  • Biomedical Engineering


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