AMPA receptors and rapid synaptic transmission

Laurence Trussell, Indira M. Raman, Su Zhang

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Excitatory synaptic transmission in the vertebrate central nervous system (CNS) is mediated predominantly by glutamate receptors. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate)-sensitive glutamate receptors are endowed with kinetic properties which allow them to transmit fast repetitive signals. At some synapses in the CNS, the rapid onset of desensitization of AMPA receptors limits the duration or amplitude of synaptic events. Combining different AMPA receptor subunits may generate receptors specialized for encoding signals in specific neural pathways. Additionally, synaptic strength may be controlled by protein kinases acting directly on AMPA receptors.

Original languageEnglish (US)
Pages (from-to)71-79
Number of pages9
JournalSeminars in Neuroscience
Volume6
Issue number2
DOIs
Publication statusPublished - Apr 1994
Externally publishedYes

    Fingerprint

Keywords

  • glutamate/quisqualate/plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this