Amniotic fluid volume responses to amnio-infusion of amniotic fluid versus lactated Ringer's solution in fetal sheep

Robert A. Brace, Cecilia Cheung

Research output: Contribution to journalArticle

5 Scopus citations


The present study tested the hypothesis that an intra-amniotic infusion of amniotic fluid (AF) would produce a more sustained increase in AF volume than an infusion of lactated Ringer's solution. Five chronically catheterized, late-gestation fetal sheep were studied over two 5-day periods with AF volume measured daily. After baseline measurements on day 1, 1 L of either warmed, previously frozen AF or warmed lactated Ringer's solution was infused intra-amniotically over 60 minutes. Two days later, the other fluid was infused. During the second week, fluids were infused in the opposite order. Analysis of variance (ANOVA) was used for statistical testing. Following intra-amniotic infusion (n = 20) of 1007 ± 7 (SE) mL of either AF or Ringer's solution, intra-amniotic retention of the infused fluid was only moderate after 1 day (37.2% ± 7.9%, P

Original languageEnglish (US)
Pages (from-to)363-368
Number of pages6
JournalJournal of the Society for Gynecologic Investigation
Issue number6
StatePublished - Sep 2004
Externally publishedYes



  • amnio-infusion
  • Amniotic fluid volume
  • sheep

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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