Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes

C. Andrew Combs, Michael Gravett, Thomas J. Garite, Durlin E. Hickok, Jodi Lapidus, Richard Porreco, Julie Rael, Thomas Grove, Terry Morgan, William Clewell, Hugh Miller, David Luthy, Leonardo Pereira, Michael Nageotte, Peter A. Robilio, Stephen Fortunato, Hyagriv Simhan, Jason K. Baxter, Erol Amon, Albert FrancoKenneth Trofatter, Kent Heyborne

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Objective The purpose of this study was to compare intraamniotic inflammation vs microbial invasion of the amniotic cavity (MIAC) as predictors of adverse outcome in preterm labor with intact membranes. Study Design Interleukin-6 (IL-6) was measured in prospectively collected amniotic fluid from 305 women with preterm labor. MIAC was defined by amniotic fluid culture and/or detection of microbial 16S ribosomal DNA. Cases were categorized into 5 groups: infection (MIAC; IL-6, ≥11.3 ng/mL); severe inflammation (no MIAC; IL-6, ≥11.3 ng/mL); mild inflammation (no MIAC; IL-6, 2.6-11.2 ng/mL); colonization (MIAC; IL-6,

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume210
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Premature Obstetric Labor
Amniotic Fluid
Interleukin-6
Inflammation
Membranes
Infection
Ribosomal DNA

Keywords

  • chorioamnionitis
  • intraamniotic infection
  • intraamniotic inflammation
  • microbial invasion of the amniotic cavity
  • morbidity
  • preterm birth
  • preterm labor

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes. / Andrew Combs, C.; Gravett, Michael; Garite, Thomas J.; Hickok, Durlin E.; Lapidus, Jodi; Porreco, Richard; Rael, Julie; Grove, Thomas; Morgan, Terry; Clewell, William; Miller, Hugh; Luthy, David; Pereira, Leonardo; Nageotte, Michael; Robilio, Peter A.; Fortunato, Stephen; Simhan, Hyagriv; Baxter, Jason K.; Amon, Erol; Franco, Albert; Trofatter, Kenneth; Heyborne, Kent.

In: American Journal of Obstetrics and Gynecology, Vol. 210, No. 2, 02.2014.

Research output: Contribution to journalArticle

Andrew Combs, C, Gravett, M, Garite, TJ, Hickok, DE, Lapidus, J, Porreco, R, Rael, J, Grove, T, Morgan, T, Clewell, W, Miller, H, Luthy, D, Pereira, L, Nageotte, M, Robilio, PA, Fortunato, S, Simhan, H, Baxter, JK, Amon, E, Franco, A, Trofatter, K & Heyborne, K 2014, 'Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes', American Journal of Obstetrics and Gynecology, vol. 210, no. 2. https://doi.org/10.1016/j.ajog.2013.11.032
Andrew Combs, C. ; Gravett, Michael ; Garite, Thomas J. ; Hickok, Durlin E. ; Lapidus, Jodi ; Porreco, Richard ; Rael, Julie ; Grove, Thomas ; Morgan, Terry ; Clewell, William ; Miller, Hugh ; Luthy, David ; Pereira, Leonardo ; Nageotte, Michael ; Robilio, Peter A. ; Fortunato, Stephen ; Simhan, Hyagriv ; Baxter, Jason K. ; Amon, Erol ; Franco, Albert ; Trofatter, Kenneth ; Heyborne, Kent. / Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes. In: American Journal of Obstetrics and Gynecology. 2014 ; Vol. 210, No. 2.
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