Amniocentesis prior to physical exam-indicated cerclage in women with midtrimester cervical dilation: Results from the expectant management compared to physical exam-indicated cerclage international cohort study

James Airoldi, Leonardo Pereira, Amanda Cotter, Ricardo Gomez, Vincenzo Berghella, Witoon Prasertcharoensuk, Juha Rasanen, Surasith Chaithongwongwatthana, Suneeta Mittal, Etaion Kearney, Jorge E. Tolosa

Research output: Contribution to journalArticle

22 Scopus citations


We evaluated whether the performance of an amniocentesis in women with a dilated cervix presenting at less than 26 weeks and subsequently managed by a physical exam-indicated cerclage increases the risk of spontaneous preterm birth (PTB) less than 28 weeks. Women between 150/7 to 256/7 weeks' gestation with a dilated cervix (1 to 4 cm) were identified. Multiple exclusion criteria were designated. The primary outcome was PTB less than 28 weeks. One hundred twenty-two women with a dilated cervix between 15 and 256/7 weeks gestational age were identified. Twenty-four (20%) of these had an amniocentesis performed. The unadjusted rate of PTB < 28 weeks differed between women who underwent amniocentesis compared with those who did not (58% versus 34%, respectively, p = 0.02), but after multivariate regression analysis, the performance of an amniocentesis was not an independent contributor to PTB < 28 weeks (p = 0.90). The performance of an amniocentesis prior to cerclage did not independently contribute to PTB less than 28 weeks.

Original languageEnglish (US)
Pages (from-to)63-68
Number of pages6
JournalAmerican journal of perinatology
Issue number1
StatePublished - Jan 1 2009



  • Amniocentesis
  • Cerclage
  • Intra-amniotic infection
  • Preterm birth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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