Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic γ-diketone that induces proximal neurofilamentous axonopathy

Medicine & Life Sciences

• 1,2-diacetylbenzene 100%
• 2,5-hexanedione 38%
• Amino Acids 32%
• Lysine 29%
• Ninhydrin 24%
• 2,4-hexanedione 17%
• Proteins 16%
• Intermediate Filaments 16%
• Microtubule Proteins 10%
• Neurofilament Proteins 10%
• Protein Subunits 8%
• Peripheral Nervous System 8%
• Tubulin 8%
• Polymerization 7%
• Microtubules 7%
• Polymers 6%
• In Vitro Techniques 6%
• Rodentia 6%
• Central Nervous System 5%

Chemical Compounds

• 2,5-hexanedione 31%
• Protein 18%
• Ninhydrin 16%
• Acid 15%
• Neurotoxic 8%
• Lysine 6%
• Chromophore 5%
• Polymerization Reaction 3%