Amanita smithiana mushroom ingestion: A case of delayed renal failure and literature review

Patrick L. West, Janet Lindgren, B. Zane Horowitz

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Introduction: In the Pacific Northwest a new pattern of mushroom ingestion has emerged, attributed to Amanita smithiana, in which renal failure has been the predominant manifestation. Case Report: A 55-year-old male ate 3 raw wild mushrooms in a salad and had onset of severe nausea and vomiting within 6 hours. His vital signs were unremarkable. His labs were significant for a BUN of 14mg/dL (5.0 mmol/L), and a creatinine of 1.0 mg/dL (88umol/L), transaminases were elevated with an AST of 56 U/L (nl 9-40) and an ALT of 131 U/L (nl 14-72). Treatment was initiated with N-acetyl cysteine, penicillin, and milk thistle extract on the presumption that this was an amanitin-toxin containing mushroom. He developed acute renal failure that was not responsive to our treatment. Dialysis started on day 4 with a creatinine of 6.5 mg/dL, which peaked on day 7 at 10.2 mg/dL. We were able to obtain a positive mushroom identification by a mycologist as Amanita smithiana. The patient was discharged from the hospital for outpatient dialysis on day 10 and dialysis catheter was removed 39 days after ingestion with a creatinine of 1.4 mg/dL (123.8 umol/L). Discussion: Amanita smithiana mushroom poisoning presents within 6 hours of ingestion with GI toxicity, and develops delayed onset of renal insufficiency over the first 1 to 4 days. The early hospitalization of this case allowed a profile of the onset of liver and renal injury. Mild elevation of hepatic transaminases occurred on presentation and peaked 24 hours after the ingestion. Renal injury was detected 1 day after presentation, and progressed to require hemodialysis by 4 days postingestion. This pattern of delayed-onset renal toxic mushroom ingestion is emerging among mushroom ingestions in Western North America.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalJournal of Medical Toxicology
Issue number1
StatePublished - 2009


  • Amanita smithiana
  • Dialysis
  • Mushroom ingestion
  • Renal failure

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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