Alzheimer disease and mortality

A 15-year epidemiological study

Mary Ganguli, Hiroko Dodge, Changyu Shen, Rajesh S. Pandav, Steven T. DeKosky

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Background: Alzheimer disease (AD) is considered a leading cause of death, but few studies have examined the contribution of AD to mortality based on follow-up of representative US cohorts. Objective: To examine mortality rates, duration of survival, causes of death, and the contribution of AD to the risk of mortality in an aging community-based cohort, controlling for other predictors. Design: Fifteen-year prospective epidemiological study. Mortality rates per 1000 person-years and the population-attributable risk of mortality were determined. Cox proportional hazards models were used to estimate relative risk of mortality due to AD, adjusting for relevant covariates. Death certificates were abstracted for listed causes of death. Setting: A largely blue-collar rural community in south-western Pennsylvania. Participants: A community-based cohort of 1670 adults 65 years and older at study enrollment. Main Outcome Measure: Mortality. Results: In the overall cohort, AD was a significant predictor of mortality, with a hazard ratio of 1.4 after adjusting for covariates. The population-attributable risk of mortality from AD was 4.9% based on the same model. Examining the sexes separately, AD increased mortality risk only among women. Death certificates of AD subjects were more likely to list dementia/AD, other brain disorders, pneumonia, and dehydration, and less likely to include cancer. Conclusions: Alzheimer disease was responsible for 4.9% of the deaths in this elderly cohort. Alzheimer disease increased the risk of mortality 40% in the cohort as a whole and separately in women but not in men. The mean (SD) duration of survival with AD was 5.9 (3.7) years, and longer with earlier age at onset.

Original languageEnglish (US)
Pages (from-to)779-784
Number of pages6
JournalArchives of Neurology
Volume62
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

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Epidemiologic Studies
Alzheimer Disease
Mortality
Cause of Death
Death Certificates
Alzheimer's Disease
Survival
Brain Diseases
Rural Population
Dehydration
Age of Onset
Proportional Hazards Models
Population
Dementia
Cohort
Pneumonia
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alzheimer disease and mortality : A 15-year epidemiological study. / Ganguli, Mary; Dodge, Hiroko; Shen, Changyu; Pandav, Rajesh S.; DeKosky, Steven T.

In: Archives of Neurology, Vol. 62, No. 5, 05.2005, p. 779-784.

Research output: Contribution to journalArticle

Ganguli, Mary ; Dodge, Hiroko ; Shen, Changyu ; Pandav, Rajesh S. ; DeKosky, Steven T. / Alzheimer disease and mortality : A 15-year epidemiological study. In: Archives of Neurology. 2005 ; Vol. 62, No. 5. pp. 779-784.
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