Alternative splicing increases the diversity of the human protein kinase C family

Lisa Coussens, L. Rhee, P. J. Parker, A. Ullrich

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Isolation of two protein kinase C (PKC) cDNA clones containing divergent carboxy-terminal sequences suggested a common genetic origin for these cDNAs. Partial characterization of the hPKCβ chromosomal gene provided direct evidence for the existence of two adjacent carboxy-terminal exons (β1 and β2) that are alternatively spliced to generate two types of hPKCβ sequences. PKCβ1 and β2 mRNAs are expressed in a selective manner in both human hematopoietic cells and bovine brain tissues.

Original languageEnglish (US)
Pages (from-to)389-394
Number of pages6
JournalDNA
Volume6
Issue number5
StatePublished - 1987
Externally publishedYes

Fingerprint

Alternative Splicing
Protein Kinase C
Complementary DNA
Exons
Brain
Clone Cells
Genes
Tissue
Messenger RNA

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

Cite this

Coussens, L., Rhee, L., Parker, P. J., & Ullrich, A. (1987). Alternative splicing increases the diversity of the human protein kinase C family. DNA, 6(5), 389-394.

Alternative splicing increases the diversity of the human protein kinase C family. / Coussens, Lisa; Rhee, L.; Parker, P. J.; Ullrich, A.

In: DNA, Vol. 6, No. 5, 1987, p. 389-394.

Research output: Contribution to journalArticle

Coussens, L, Rhee, L, Parker, PJ & Ullrich, A 1987, 'Alternative splicing increases the diversity of the human protein kinase C family', DNA, vol. 6, no. 5, pp. 389-394.
Coussens, Lisa ; Rhee, L. ; Parker, P. J. ; Ullrich, A. / Alternative splicing increases the diversity of the human protein kinase C family. In: DNA. 1987 ; Vol. 6, No. 5. pp. 389-394.
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