Alternative Splicing Increases the Diversity of the Human Protein Kinase C Family

Lisa Coussens, Lucy Rhee, Peter J. Parker, Axel Ullrich

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Isolation of two protein kinase C(PKC) Cdna clones containing divergent carboxy-terminal sequences suggested a common genetic origin for these cDNAs. Partial characterization of the hPKcβ chromosomal gene provided direct evidence for the existence of two adjacent carboxy-terminal exons (β, and β2) that are alternatively spliced to generate two types of Hpkcβ sequences. Pkcβ, and β2 Mrnas are expressed in a selective manner in both human hematopoietic cells and bovine brain tissues.

Original languageEnglish (US)
Pages (from-to)389-394
Number of pages6
JournalDNA
Volume6
Issue number5
DOIs
StatePublished - Oct 1987

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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