Altered responsiveness of medial prefrontal cortex neurons to glutamate and dopamine after withdrawal from repeated amphetamine treatment

Jayms D. Peterson; Marina E. Wolf; Francis J. White

doi:10.1002/(SICI)1098-2396(20000615)36:4<342::AID-SYN11>3.0.CO;2-9

Altered responsiveness of medial prefrontal cortex neurons to glutamate and dopamine after withdrawal from repeated amphetamine treatment

Jayms D. Peterson, Marina E. Wolf, Francis J. White

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Using in vive extracellular single-cell recording and microiontophoresis, we compared the responsiveness of medial prefrontal cortex (mPFC) neurons (layers V-VI) to dopamine and glutamate in rats that had received repeated amphetamine or saline injections. Neurons from amphetamine-pretreated rats showed increased responsiveness to glutamate and decreased responsiveness to dopamine after three days of withdrawal, suggesting that the mPFC is transiently hyperexcitable during amphetamine withdrawal.

Original language	English (US)
Pages (from-to)	342-344
Number of pages	3
Journal	Synapse
Volume	36
Issue number	4
DOIs	https://doi.org/10.1002/(SICI)1098-2396(20000615)36:4<342::AID-SYN11>3.0.CO;2-9
State	Published - Jun 15 2000
Externally published	Yes

Keywords

Behavioral sensitization
Excitatory amino acids

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

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10.1002/(SICI)1098-2396(20000615)36:4<342::AID-SYN11>3.0.CO;2-9

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Altered responsiveness of medial prefrontal cortex neurons to glutamate and dopamine after withdrawal from repeated amphetamine treatment

Abstract

Keywords

ASJC Scopus subject areas

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