Using in vive extracellular single-cell recording and microiontophoresis, we compared the responsiveness of medial prefrontal cortex (mPFC) neurons (layers V-VI) to dopamine and glutamate in rats that had received repeated amphetamine or saline injections. Neurons from amphetamine-pretreated rats showed increased responsiveness to glutamate and decreased responsiveness to dopamine after three days of withdrawal, suggesting that the mPFC is transiently hyperexcitable during amphetamine withdrawal.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jun 15 2000|
- Behavioral sensitization
- Excitatory amino acids
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience