Altered responsiveness of medial prefrontal cortex neurons to glutamate and dopamine after withdrawal from repeated amphetamine treatment

Jayms D. Peterson, Marina E. Wolf, Francis J. White

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Using in vive extracellular single-cell recording and microiontophoresis, we compared the responsiveness of medial prefrontal cortex (mPFC) neurons (layers V-VI) to dopamine and glutamate in rats that had received repeated amphetamine or saline injections. Neurons from amphetamine-pretreated rats showed increased responsiveness to glutamate and decreased responsiveness to dopamine after three days of withdrawal, suggesting that the mPFC is transiently hyperexcitable during amphetamine withdrawal.

Original languageEnglish (US)
Pages (from-to)342-344
Number of pages3
JournalSynapse
Volume36
Issue number4
DOIs
StatePublished - Jun 15 2000

Keywords

  • Behavioral sensitization
  • Excitatory amino acids

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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