Altered redox state and apoptosis in the pathogenesis of systemic lupus erythematosus

Dilip Shah, Sangita Sah, Ajay Wanchu, Mei X. Wu, Archana Bhatnagar

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

An altered redox status and increased lymphocyte apoptosis have been implicated in the development of systemic lupus erythematosus (SLE). In this study, we evaluated the relationship between glutathione (GSH) depletion, reactive oxygen species (ROS) and, the progression of apoptosis and their association with SLE severity. Significant low levels of intracellular glutathione, total thiol and altered redox state (GSH/GSSG) were found in SLE patients, in which lymphocyte apoptosis and activated caspase-3 expression in the lymphocytes were remarkably increased. The severity of disease was positively allied with the increased levels of lymphocyte apoptosis and caspase-3, but negatively with the decreased levels of total thiol, depleted intracellular glutathione and altered redox state (GSH/GSSG). The lymphocyte apoptosis and activated caspase-3 expression were negatively associated with intracellular levels of GSH and redox state and positively associated with the elevated levels of multiple oxidative stress markers; ROS and lipid peroxidation measured as malondialdehyde (MDA). These results suggest that GSH depletion and elevated oxidative stress trigger apoptosis and may be coupled with the severity of the disease.

Original languageEnglish (US)
Pages (from-to)620-627
Number of pages8
JournalImmunobiology
Volume218
Issue number4
DOIs
StatePublished - Apr 1 2013

Keywords

  • Altered redox state
  • Apoptosis
  • CGlutathione
  • Systemic lupus erythematosus (SLE)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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