Altered patterns of T cell cytokine production induced by relapsed pre-B ALL cells

Gregor S D Reid, Luke Terrett, Angela J. Alessandri, Stacey Grubb, Linda Stork, Nita Seibel, Paul Gaynon, Kirk R. Schultz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Relapse of pediatric acute lymphoblastic leukemia (ALL) remains a significant clinical problem. The graft-versus-leukemia (GVL) effect after hematopoietic stem cell transplantation indicates that immune mechanisms may play a role in the control of ALL blasts. In this study, we analyzed primary diagnostic and relapsed pre-B ALL samples for the surface expression of several molecules implicated in immune responses and for the induction of allogeneic T cell responses. There were no significant differences in the expression of CD11a, CD40, CD80 and CD86 or MHC classes I and II molecules between the diagnostic and relapsed samples. We found no significant differences in the overall ability of diagnostic and relapsed pre-B ALL samples to induce T cell proliferation and cytokine production. However, in the case of T cell responses induced by diagnostic ALL samples, there was excellent correlation between proliferation and production of all cytokines analyzed. In the case of relapsed samples, the only correlation obtained was with IL-5. This observation indicates that the nature of the immune response generated by relapsed ALL cells in an allogeneic setting differs from that obtained with diagnostic samples, suggests a biasing towards a Th2 response may contribute to the evasion of effective immune responses by relapsed ALL.

Original languageEnglish (US)
Pages (from-to)1135-1142
Number of pages8
JournalLeukemia Research
Volume27
Issue number12
DOIs
StatePublished - Dec 1 2003

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cytokines
T-Lymphocytes
Immune Evasion
Hematopoietic Stem Cell Transplantation
Interleukin-5
Leukemia
Cell Proliferation
Pediatrics
Transplants
Recurrence

Keywords

  • Acute lymphoblastic leukemia
  • Costimulation
  • Cytokines
  • Immune response
  • Relapse
  • T cells

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Reid, G. S. D., Terrett, L., Alessandri, A. J., Grubb, S., Stork, L., Seibel, N., ... Schultz, K. R. (2003). Altered patterns of T cell cytokine production induced by relapsed pre-B ALL cells. Leukemia Research, 27(12), 1135-1142. https://doi.org/10.1016/S0145-2126(03)00106-1

Altered patterns of T cell cytokine production induced by relapsed pre-B ALL cells. / Reid, Gregor S D; Terrett, Luke; Alessandri, Angela J.; Grubb, Stacey; Stork, Linda; Seibel, Nita; Gaynon, Paul; Schultz, Kirk R.

In: Leukemia Research, Vol. 27, No. 12, 01.12.2003, p. 1135-1142.

Research output: Contribution to journalArticle

Reid, GSD, Terrett, L, Alessandri, AJ, Grubb, S, Stork, L, Seibel, N, Gaynon, P & Schultz, KR 2003, 'Altered patterns of T cell cytokine production induced by relapsed pre-B ALL cells', Leukemia Research, vol. 27, no. 12, pp. 1135-1142. https://doi.org/10.1016/S0145-2126(03)00106-1
Reid, Gregor S D ; Terrett, Luke ; Alessandri, Angela J. ; Grubb, Stacey ; Stork, Linda ; Seibel, Nita ; Gaynon, Paul ; Schultz, Kirk R. / Altered patterns of T cell cytokine production induced by relapsed pre-B ALL cells. In: Leukemia Research. 2003 ; Vol. 27, No. 12. pp. 1135-1142.
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